Evidence map›Paper›PMID 42004620›Full record

ArticleBioactive materials2026

A dual-functional engineered exosome-laden hydrogel redirects endogenous neural stem cell fate for spinal cord injury repair.

Wenxiang Li, Wencan Zhang, Han Zheng, Yang Zhang, Yanbin Feng, Yujia Xie, Xuanrui Liu, Mingshan Liu, Xiaohong Kong, Ning Ran and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenxiang LiDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.
Wencan ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China.
Han ZhengDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.
Yang ZhangSchool of Basic Medical Sciences, Beijing Key Laboratory of Neural Regeneration and Repair, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, 100069, PR China.
Yanbin FengDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.
Yujia XieDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.
Xuanrui LiuDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.
Mingshan LiuDepartment of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100000, PR China.
Xiaohong KongDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.
Ning RanDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.
Shiqing FengDepartment of Orthopedics, The Second Qilu Hospital of Shandong University, Shandong University Centre for Orthopedics, Cheeloo College of Medicine, Shandong University, Jinan, 250033, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) repair is severely restricted by a hostile post-injury microenvironment that drives endogenous neural stem cells (eNSCs) toward astroglial scar formation rather than neuronal regeneration. Here, we developed a dual-functional "molecule-carrier-scaffold" strategy that combines engineered exosomes with a sustained-release hydrogel to simultaneously remodel the inflammatory niche and redirect eNSCs fate. Human umbilical cord mesenchymal stem cell-derived exosomes were engineered to display a neurotrophic factor cocktail (GDNF/NT3/IGF1; termed EXO

Indexed as

Cell fate redirectionEndogenous neural stem cellsEngineered exosomesNeural regenerationSpinal cord injurySustained-release hydrogel scaffold

Identifiers

PMID42004620
PMCPMC13091388

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.