Evidence map›Paper›PMID 42004618›Full record

ArticleBioactive materials2026

Nose-to-brain administration of cannabidiol-loaded polymeric micelles improves the core behavioral symptoms of autism spectrum disorder.

Rania Awad, Shlomit Aga-Mizrachi, Inon Maoz, Lilach Simchi, Avi Avital, Alejandro Sosnik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rania AwadLaboratory of Pharmaceutical Nanomaterials Science, Faculty of Materials Science and Engineering, Technion - Israel Institute of Technology, Haifa, Israel.
Shlomit Aga-MizrachiDepartment of Occupational Therapy, Faculty of Heath Sciences, University of Haifa, Haifa, Israel.
Inon MaozDepartment of Occupational Therapy, Faculty of Heath Sciences, University of Haifa, Haifa, Israel.
Lilach SimchiDepartment of Occupational Therapy, Faculty of Heath Sciences, University of Haifa, Haifa, Israel.
Avi AvitalDepartment of Occupational Therapy, Faculty of Heath Sciences, University of Haifa, Haifa, Israel.
Alejandro SosnikLaboratory of Pharmaceutical Nanomaterials Science, Faculty of Materials Science and Engineering, Technion - Israel Institute of Technology, Haifa, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodevelopmental disorders including autism spectrum disorder (ASD) affect 5.9% of the global population. Research shows the potential therapeutic use of cannabidiol (CBD) to treat different neurodevelopmental disorders, including ASD. Intranasal drug delivery (i.n.) is a non-invasive and painless administration route that enhances drug bioavailability in the brain bypassing the blood-brain barrier. Various polymeric nanoparticles have been investigated for i.n. delivery with different success levels. In this study, we developed and characterized polymeric micelles of the poly(ethylene oxide)-

Indexed as

Autism spectrum disorderCannabidiol-loaded polymeric micellesNose-to-brain drug deliverySocial cooperation

Identifiers

PMID42004618
PMCPMC13084693

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.