ArticleFrontiers in pharmacology2026
Protective effect of wild polysaccharides extracted from
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder, with prenatal exposure to valproic acid (VPA) being a recognized environmental risk factor for ASD, closely associated with its neurotoxic mechanism and oxidative stress. Marine green algae, such as Method: The primary structure of PUPs was determined through infrared spectroscopy, liquid chromatography, and gel permeation chromatography. PUPs intervention in the VPA-induced HT22 oxidative damage cell model was used to measure oxidative stress factor levels. Results: PUPs were characterized as composite polysaccharides with α-glycosidic bonds, sulfate ions, and aldonic acids, containing mannose, rhamnose, glucuronic acid, glucose, galactose, and xylose. The main molecular weight (Mw) was 2.124 kDa (80.535%). Conclusions: PUPs demonstrate a significant protective effect against VPA-induced oxidative stress damage in HT22 neuronal cells. As a natural antioxidant, PUPs hold promising potential for the prevention and adjunct treatment of ASD-related neuronal oxidative stress damage.
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