ArticleIranian journal of basic medical sciences2026
An
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
Objectives: Hepatic fibrosis is a major cause of liver-related mortality worldwide. This study evaluated the hepatoprotective and antifibrotic effects of inulin, a natural polysaccharide, in a rat model of cholestasis induced by bile duct ligation (BDL). Materials and Methods: Thirty male Wistar rats (230-250 g) were randomly divided into six groups: control, sham, inulin (200 mg/kg), BDL, and BDL+ inulin (100 and 200 mg/kg). Inulin was orally administered for 30 days after BDL. Serum liver enzyme levels, bilirubin, and lipid profiles were measured. Liver tissues were analyzed for oxidative stress markers (GPx, MDA), fibrogenic mediators (TGF-β1, α-SMA) via immunohistochemistry, and FXR levels by ELISA. Histological changes were evaluated by ELISA and Masson's trichrome staining. Results: At 200 mg/kg, inulin significantly reversed the BDL-induced increases in serum liver enzymes (AST, ALT, and ALP), total bilirubin, and cholesterol ( Conclusion: These findings suggest that inulin may exert antifibrotic effects through its anti-oxidant activity, ultimately reducing the expression of fibrogenic markers. This study presents strong histological evidence to support the hepatoprotective role of inulin.
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