Whole-blood transcriptomic response to whole-body hyperthermia in participants with major depressive disorder.

Tyler N Akonom, Mary A Allen, Tommy K Begay, Ashley E Mason, Steven P Cole, Charles L Raison, Christopher A Lowry

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In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Tyler N AkonomDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.

Mary A AllenBioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80309, USA.

Tommy K BegaySleep and Health Research Program, University of Arizona College of Medicine, Tucson, AZ 85724, USA.

Ashley E MasonOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.

Steven P ColeResearch Design Associates Inc, Yorktown Heights, NY 10598, USA.

Charles L RaisonDepartment of Psychiatry, School of Medicine and Public Health, University of Wisconsin-Madison, WI 53719, USA.

Christopher A LowryDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depression is the leading cause of global disability according to the World Health Organization. Current pharmacologic interventions suffer from significant limitations and side effects, highlighting a need for novel therapeutic approaches. Whole-body hyperthermia (WBH) has been identified as a promising avenue of treatment of major depressive disorder (MDD); however, the mechanisms responsible for the antidepressant effects of WBH are not completely understood. In a previously published trial, we randomized adults with moderate to severe MDD (Hamilton Depression Rating Scale (HDRS) score >16) to one of two interventions (WBH or sham WBH). We collected whole blood 30 min post-intervention and followed participants for 6 weeks. In these analyses, we used a high-throughput RNA sequencing (RNA-seq) approach to compare the whole-blood transcriptomic response 30 min post-intervention. Differentially expressed gene (DEG) analysis with a Benjamini-Hochberg false discovery rate (FDR)-adjusted

Identifiers

PMID42004495

DOI10.1016/j.bbih.2026.101225

PMCPMC13089122

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.