Evidence map›Paper›PMID 42004494›Full record

ArticleBrain, behavior, & immunity - health2026

Chronic inflammation is associated with increased anxiety in the Cancer Disparities Research Network.

Holli Loomans-Kropp, Priya Das, Aaliyah Beneby, Yevgeniya Gokun, Laura Yonghua Bao, Wancai Yang, Ting-Yuan David Cheng, Jill Oliveri, Mohamed Elsaid, Roberto Benzo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Holli Loomans-KroppDivision of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, 43214, USA.
Priya DasComprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Aaliyah BenebyCentral State University, Wilberforce, OH, 45384, USA.
Yevgeniya GokunCenter for Biostatistics, The Ohio State University, Columbus, OH, 43210, USA.
Laura Yonghua BaoComprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Wancai YangComprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Ting-Yuan David ChengDivision of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, 43214, USA.
Jill OliveriComprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Mohamed ElsaidComprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Roberto BenzoDivision of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, 43214, USA.
Electra PaskettDivision of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH, 43214, USA.
Cancer Disparities Research Network Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Systemic chronic inflammation is associated with the development of diseases, such as diabetes and cancer. Recent research has shown that psychological state can influence inflammation, demonstrating the mind-body connection; however, there is limited knowledge on whether self-perception of quality of life has physiological effects on systemic chronic inflammatory biomarkers among healthy individuals. Furthermore, there is a gap in the literature on this connection among minoritized and underserved populations, despite known increased chronic stress. The objective of the current study is to evaluate the association between quality-of-life measures, such as anxiety, and blood-based inflammation markers in the Cancer Disparities Research Network (CDRN), which recruited a study population of individuals who were minoritized or medically underserved. CDRN participants were recruited from four institutions between January 2015 and April 2017 and asked to complete a baseline survey and provide a biospecimen. Biomarkers were measured using customized human analyte assay kits. Of the measured markers, six were significantly correlated with overall anxiety and not significantly correlated with other measured markers. Using multivariate linear regressions, we found that mild and moderate/severe anxiety were significantly associated with gp130 and MMP-1 concentration, and moderate/severe anxiety was associated with APRIL concentration. These findings emphasize the importance of psychological well-being and its potential long-term influence on physical health and disease progression.

Indexed as

AnxietyChronic inflammationHealth disparitiesMolecular biomarkersQuality of life

Identifiers

PMID42004494
PMCPMC13090683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.