Bioactive derivatives of the antimicrobial peptide esculentin-1a promote human dermal fibroblast migration and activate genes involved in early wound healing.

Floriana Cappiello, Eleonora Grisard, Alice Traversa, Danilo Ranieri, Maria Luisa Mangoni

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Article in BBA advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Floriana CappielloLaboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Eleonora GrisardLaboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Alice TraversaDepartment of Life Science, Health, and Health Professions, Link Campus University, 00165 Rome, Italy.

Danilo RanieriDepartment of Life Science, Health, and Health Professions, Link Campus University, 00165 Rome, Italy.

Maria Luisa MangoniLaboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, 00185 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are essential components of the innate immune system and have emerged as promising candidates against antibiotic-resistant infections. Beyond their antimicrobial activity, AMPs also play a crucial role in regulating tissue regeneration processes, including wound healing. Previous studies have shown that the frog skin-derived AMP, esculentin-1a(1-21) [Esc(1-21)], promotes wound healing by accelerating keratinocyte migration. Its derivative, esculentin-1a(1-21)-1c [Esc(1-21)-1c] has proven even more effective in facilitating wound closure in alveolar and bronchial epithelial cell monolayers. Given the essential role of dermal fibroblasts in skin regeneration, this study aimed to investigate the effects of Esc(1-21) and its two derivatives, Esc(1-21)-1c and [Aib

Indexed as

Antimicrobial peptidesHuman dermal fibroblastsMAPK/ERK pathwayWound healing

Identifiers

PMID42004462

DOI10.1016/j.bbadva.2026.100186

PMCPMC13087719

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.