ReviewReproductive medicine and biology
Functional Impairment of Activated Regulatory T Cells as a Central Immunological Defect in Endometriosis.
Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Endometriosis-Associated Infertility in China: Epidemiological Trends, Future Projection, and Real-World Clinical Insights.International journal of women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endometriosis is increasingly recognized as a disorder of impaired reproductive immune tolerance rather than solely an endocrine disease. Although previous studies have reported inconsistent findings regarding the number of regulatory T cells (Tregs), the functional integrity of distinct Treg subsets and their contribution to disease pathogenesis remains unclear. Methods: We reviewed clinical, experimental, and translational studies focusing on regulatory T-cell biology in endometriosis, with emphasis on functional Treg subsets, immune interactions within ectopic lesions, and emerging immunomodulatory therapeutic approaches. Main Findings: Accumulating evidence indicates that endometriosis is characterized not by a reduction in total Foxp3 Conclusion: Functional impairment of activated regulatory T cells represents a central immunological defect underlying chronic inflammation, lesion persistence, and infertility in endometriosis. Restoration of Treg-mediated immune regulation may provide a promising nonhormonal, fertility-preserving therapeutic strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.