ArticleACS nanoscience Au2026
Simulated Microgravity Induces Rapid Dielectric Shifts in Erythrocytes of Pancreatic Cancer Patients.
Article in ACS nanoscience Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Machine Learning-Based Detection ofPathogens (Basel, Switzerland) · 2026Article
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4 authors.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, often diagnosed at advanced stages due to the absence of early symptoms and reliable screening tools. Recent studies suggest that systemic changes in cancer, including inflammation, metabolic alterations, and circulating biomarkers, can affect red blood cells (RBCs) or erythrocytes. Although RBCs lack nuclei, those from cancer patients exhibit measurable biophysical and biochemical alterations, offering potential for novel diagnostic approaches. However, it is not known how simulated microgravity might further modulate these cancer-associated RBC dielectric properties, and the effects of microgravity on RBCs from PDAC patients remain largely unexplored. In this study, we investigate the impact of simulated microgravity (SMG) on the dielectric properties of human red blood cells from pancreatic ductal adenocarcinoma (PDAC) patients and healthy donors as controls. Cells were exposed to SMG using a clinostat for 3 and 6 h in a suspending medium with a fixed conductivity of 0.01 S/m. Dielectrophoresis (DEP), a label-free electrokinetic technique, was used to analyze cellular responses to nonuniform electric fields ranging from 0.5 kHz to 45 MHz at a constant peak-to-peak voltage of 10
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