Evidence map›Paper›PMID 42004268›Full record

ArticleACS nanoscience Au2026

Turning on Protein Function Inhibited by DNA Aptamers Employing a Covalent DNA-Binding Protein.

Takeru Kanazu, Erika Komiya, Daimei Miura, Kaori Tsukakoshi, Kazunori Ikebukuro, Tomohiko Yamazaki, Ryutaro Asano

Abstract read
In one paragraph

Article in ACS nanoscience Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takeru KanazuDepartment of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Erika KomiyaDepartment of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.
Daimei MiuraDepartment of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.ORCID https://orcid.org/0009-0007-0005-9976
Kaori TsukakoshiDepartment of Chemistry, Faculty of Science Division I, Tokyo University of Science, 1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.ORCID https://orcid.org/0000-0003-4779-1113
Kazunori IkebukuroDepartment of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.ORCID https://orcid.org/0000-0003-2838-0562
Tomohiko YamazakiResearch Center for Macromolecules and Biomaterials, National Institute for Material Sciences (NIMS), 1-2-1 Sengen, Tsukuba, Ibaraki 305-0047, Japan.ORCID https://orcid.org/0000-0003-2136-8042
Ryutaro AsanoDepartment of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.ORCID https://orcid.org/0000-0001-6795-8377

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Certain DNA aptamers can serve as effective inhibitors, although their inhibitory action is typically unidirectional. Simple removal of these aptamers from their target complexes could improve their application in areas such as oligonucleotide therapeutics. In the current study, we used uracil-DNA glycosylase from

Indexed as

AnticoagulantDNA aptamerDNA aptamer removerUdgXuracil-DNA glycosylase

Identifiers

PMID42004268
PMCPMC13087943

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.