ReviewCardiology research and practice2026
Research Progress of Nerve Injury-Induced Protein 1 in Cardiovascular Diseases.
Review in Cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research Progress of Nerve Injury-Induced Protein 1 in Cardiovascular Diseases.Cardiology research and practice · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve injury-induced protein 1 (Ninjurin 1) is a cell surface adhesion molecule that contains one extracellular adhesion domain and two transmembrane domains. Originally discovered in nerve injury, it has been extensively studied for its role in nerve regeneration. Ninj1 mediates the transendothelial migration of myeloid cells mainly through the extracellular adhesion domain, thereby aggravating the inflammation of the central nervous system. In addition to regulating the inflammatory phenotype of cells, Ninj1 actively mediates the rupture of the plasma membrane and regulates the programmed death of inflammatory cells, thereby participating in the host defense against exogenous infection. In recent years, Ninj1, an important protein associated with inflammasome activation, has garnered increasing attention from researchers regarding its mechanistic role and pathophysiological significance in cardiovascular diseases. Accumulating evidence suggests that Ninj1 not only participates in the regulation of inflammatory responses and cell death processes but also plays a critical role in the onset and progression of various cardiovascular conditions, including atherosclerosis, myocardial ischemia-reperfusion injury, and heart failure. Therefore, an in-depth exploration of the specific functions of Ninj1 in the cardiovascular system holds significant scientific and clinical value for elucidating the molecular mechanisms underlying these diseases and for developing novel therapeutic strategies. This review aims to summarize the research progress on Ninj1 in cardiovascular diseases and to outline its mechanisms in pathological processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.