Evidence map›Paper›PMID 42004219›Full record

ArticleNIHR open research2026

Randomised controlled trial of a very brief nurse-delivered intervention followed by a digital intervention to support medication adherence and reduce blood pressure in people prescribed treatment for hypertension in primary care: protocol for the Programme on Adherence to Medication (PAM) trial.

Stephen Sutton, James Jamison, Katja Beardsell, Micah Fineberg, Raquel Conceição, Venus Mirzaei, Catalina Trama Alvarez, Sonia Shpendi, James Brimicombe, Debi Bhattacharya and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NIHR open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Stephen SuttonPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.ORCID https://orcid.org/0000-0003-1610-0404
James JamisonDivision of Psychiatry, University College London, London, W1T 7NF, UK.
Katja BeardsellDepartment of Psychology, Counselling and Therapy, School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia.ORCID https://orcid.org/0009-0001-8877-2093
Micah FinebergHealth Practice, Genesis Analytics, Johannesburg, 2196, South Africa.
Raquel ConceiçãoCambridgeshire and Peterborough NHS Foundation Trust, Cambridge, CB4 1PX, UK.
Venus MirzaeiSpecialist Children and Young People's Services, East London NHS Foundation Trust, London, E15 4PT, UK.
Catalina Trama AlvarezFrontiers Media SA, Lausanne, 1005, Switzerland.
Sonia ShpendiSchool of Psychology, University of Sheffield, Sheffield, S1 4DP, UK.
James BrimicombePrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.
Debi BhattacharyaSchool of Health Sciences, University of East Anglia, Norwich, NR4 7UL, UK.
Wendy HardemanSchool of Health Sciences, University of East Anglia, Norwich, NR4 7UL, UK.
Felix NaughtonSchool of Health Sciences, University of East Anglia, Norwich, NR4 7UL, UK.
Miranda Van EmmenisPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.ORCID https://orcid.org/0000-0002-4717-6746
Helen EborallUsher Institute, School of Population Health Sciences, University of Edinburgh, Edinburgh, EH16 4UX, UK.
Anna De SimoniWolfson Institute of Population Health, Queen Mary University of London, London, E1 2AB, UK.ORCID https://orcid.org/0000-0001-6955-0885
Amrit TakharWansford and Kings Cliffe Practice, Wansford, PE8 6PL, UK.
Pankaj GuptaDepartment of Cardiovascular Sciences, University of Leicester, Leicester, LE1 7RH, UK.
Prashanth PatelDepartment of Cardiovascular Sciences, University of Leicester, Leicester, LE1 7RH, UK.
Cecilia MascoloDepartment of Computer Science and Technology, University of Cambridge, Cambridge, CB3 0FD, UK.
Andrew Toby PrevostClinical Research Facility, Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK.
Joana Carvalho de VasconcelosClinical Research Facility, Moorfields Eye Hospital NHS Foundation Trust, London, EC1V 2PD, UK.
Jonathan MantPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.
Simon GriffinPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.
Richard J McManusBrighton and Sussex Medical School, University of Brighton and University of Sussex, Brighton, BN1 9PX, UK.
Stephen MorrisPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB2 0SR, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hypertension is a global health challenge accounting for 8.5 million deaths worldwide despite the availability of low-cost pharmaceutical treatment. About 14.9% of people (9.9 million) registered with primary care practices in England and Wales are prescribed medication for hypertension. However, many patients with hypertension and associated conditions do not take their medications as prescribed. Non-adherence to antihypertensive medication is associated with increased risk of suboptimal blood pressure (BP) control, complications and all-cause mortality, and increased healthcare costs. The Programme on Adherence to Medication (PAM) trial will estimate the effectiveness and cost-effectiveness of a medication adherence intervention in patients prescribed medication for hypertension with poorly controlled blood pressure in primary care. Methods: A two-arm multicentre individually randomised controlled parallel group superiority trial recruiting patients prescribed medication for hypertension with poorly controlled BP in primary care practices in England and Wales. The target sample size is 542. Participants in the Intervention group will receive a very brief intervention delivered remotely (by telephone or video call) by a practice nurse or healthcare assistant followed by a digital intervention (text messaging or smartphone app) in addition to usual care; control group participants will receive usual care alone. The primary outcome is systolic BP measured at 12 months. Medication adherence will be measured by chemical adherence testing of urine samples and self-report. An economic evaluation and a process evaluation will be undertaken. Ethics and dissemination: The Cambridge East Independent Research Ethics Committee (REC reference 19/EE/0354), the Health Research Authority (HRA) and Health and Care Research Wales (HCRW) approved the trial. The findings will be disseminated to the scientific community, participating practitioners and patients, relevant patient groups and the public using a range of methods, including journal articles, conference presentations, newsletters and the Programme website. Trial registration number: The UK's Clinical Trial Registry ISRCTN82013652.

Indexed as

Blood pressureDigital interventionHypertensionMedication adherencePrimary careProtocolRandomised controlled trialVery brief intervention

Identifiers

PMID42004219
PMCPMC13090759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.