ArticleAmerican journal of cancer research2026
Comparison of complete resection rate and endocrine function improvement between neuronavigation-assisted neuroendoscopic transnasal transsphenoidal approach and microscopic transcranial approach for giant pituitary adenoma.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study aimed to compare the complete resection rate and endocrine function improvement between the neuronavigation-assisted neuroendoscopic transnasal transsphenoidal approach and the microscopic transcranial approach for giant pituitary adenomas (diameter ≥4 cm). In a retrospective cohort of 300 patients, 132 underwent the transsphenoidal approach and 168 the transcranial approach. Postoperative magnetic resonance imaging revealed a significantly higher complete resection rate in the transsphenoidal group (71.21% vs. 59.52%, P=0.036). At two weeks postoperatively, the transsphenoidal group demonstrated significantly better outcomes in endocrine function, visual field parameters, and surgical indicators (shorter operation time, less blood loss, and shorter postoperative stay), with a lower overall complication rate (13.64% vs. 23.21%, P=0.036). Multivariate analysis identified the transsphenoidal approach as an independent protective factor against incomplete resection. In conclusion, for selected giant pituitary adenomas, the neuronavigation-assisted neuroendoscopic transnasal transsphenoidal approach may be superior to the microscopic transcranial approach in achieving higher rates of complete resection, better endocrine and visual recovery, and reduced surgical trauma.
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