ReviewAmerican journal of cancer research2026
Ferroptosis and Ferroptosis-related autophagy: new therapeutic targets for gastric cancer.
Review in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Gastric cancer (GC) is still the biggest factor in cancer-related death worldwide, and existing therapies have low therapeutic effectiveness. A possible cancer treatment target is ferroptosis, an iron-dependent kind of lipid peroxidation-induced regulated cell death. Recent studies further reveal that autophagy associated with ferroptosis modulates ferroptosis by regulating iron homeostasis, lipid metabolism, and redox balance. This review systematically describes the role of ferroptosis-related autophagy and ferroptosis in the pathogenesis and development of GC. We highlight key molecular mechanisms and propose ferroptosis-related biomarkers as potential diagnostic and therapeutic targets. Our findings underscore the translational potential of targeting ferroptosis-autophagy networks for GC treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.