ArticleAmerican journal of cancer research2026
Predictive value of the systemic immune-inflammation index and geriatric nutritional risk index on the efficacy of immunotherapy and survival prognosis in advanced non-small cell lung cancer: a retrospective study.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the predictive value of the systemic immune-inflammation index (SII) and geriatric nutritional risk index (GNRI) for immunotherapy efficacy and survival prognosis in advanced non-small cell lung cancer (NSCLC).
methodsThis retrospective study enrolled 152 patients with advanced NSCLC who received immunotherapy. Patients were divided into effective (n = 106) and ineffective (n = 46) groups based on treatment response. Pretreatment SII, GNRI, and programmed cell death-ligand 1 (PD-L1) levels were compared between groups. Multivariate logistc regression identified factors influencing immunotherapy efficacy. Receiver operating characteristic curve analysis evaluated the predictive value of these indicators. Kaplan-Meier method analyzed the relationship between SII, GNRI, and progression-free survival (PFS)/overall survival (OS). Cox regression analyzed their impact on survival and interaction.
resultsThe effective group had significantly lower pretreatment SII but higher GNRI and PD-L1 than the ineffective group (all
conclusionsSII and GNRI are closely associated with immunotherapy efficacy in advanced NSCLC, and their interaction influences patient survival.
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