ArticleJPRAS open2026
Local dexamethasone and magnesium sulfate for postoperative pain management in septorhinoplasty: A clinical evaluation.
Article in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Septorhinoplasty is one of the most common cosmetic surgical procedures performed today, and like other surgeries, it may be accompanied by complications. Postoperative pain control is an important aspect of patient management. Objective: This study aimed to evaluate the effect of dexamethasone and magnesium sulfate on reducing pain intensity and hemodynamic changes after septorhinoplasty. Methods: This double-blind, randomized controlled clinical trial included 60 patients undergoing septorhinoplasty who were randomly assigned to two groups: the S group (magnesium sulfate and dexamethasone) and the C group (control). Patients in the S group received a combination of magnesium sulfate and dexamethasone at a rate of 5-10 µg/kg/min. Patients in the C group received an equal volume of normal saline instead. Mean changes in blood pressure, heart rate, opioid consumption, and pain scores were monitored for 6 h after surgery. Results: Eighteen female and twelve male patients in the intervention group received magnesium sulfate and dexamethasone, with a mean age of 26.3 ± 7.2 years. At 1, 2, 4, and 6 h postoperatively, hemodynamic changes were significantly lower compared to the control group. No adverse effects were observed during surgery or hospitalization. Conclusions: This study demonstrates the positive effect of combined magnesium sulfate and dexamethasone in reducing postoperative pain after septorhinoplasty, with no acute or short-term complications observed.
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