ArticleFrontiers in human neuroscience2026
Serum creatinine outperforms the creatinine to cystatin C ratio and creatinine muscle index as biomarkers in Chinese pediatric spinal muscular atrophy.
Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to validate the utility of serum creatinine (Cr), creatinine-to-cystatin C ratio (CCR) and creatinine muscle index (CMI) as biomarkers in Chinese pediatric patients with spinal muscular atrophy (SMA). Methods: A retrospective cohort of 21 pediatric patients with 5q-spinal muscular atrophy (5q-SMA) was followed over 18-month after initiating nusinersen therapy. Serum biomarkers (creatinine, cystatin C, and albumin) and multidimensional motor function scores were assessed at six predefined time points. Associations between serum markers and motor function outcomes were analyzed statistically. Results: A robust and sustained correlation was identified between Cr levels and all motor function metrics-both at baseline and during follow-up (Spearman's Conclusion: Routinely measured Cr is a more reliable dynamic biomarker than CCR and CMI for assessing therapeutic response in pediatric SMA patients undergoing nusinersen treatment.
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