Evidence map›Paper›PMID 42003962›Full record

ReviewInfection and drug resistance2026

The Upcoming Antifungal Drugs in Clinical Development for the Treatment of Invasive Candidiasis.

Anna Zubovskaia, Jose A Vazquez

Abstract readReview
In one paragraph

Review in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anna ZubovskaiaDivision of Infectious Diseases, Department of Medicine, Wellstar MCG/Augusta University, Augusta, GA, USA.
Jose A VazquezDivision of Infectious Diseases, Department of Medicine, Wellstar MCG/Augusta University, Augusta, GA, USA.ORCID 0000-0001-5774-819X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Invasive candidiasis (IC) is a major cause of morbidity and mortality among hospitalized patients, and treatment success relies on early diagnosis and prompt initiation of an appropriate antifungal agent. The increasing rates of resistance to first-line antifungal agents (azoles, echinocandins, and polyenes), along with changes in the epidemiology of IC and the spread of multidrug-resistant Areas Covered: We will discuss the spectrum of activity of novel antifungal agents, mechanisms or resistance, pertinent in vivo and vitro data, as well as data from the clinical trials evaluating efficacy and safety of novel antifungals. Expert Opinion: Rezafungin holds promise as an excellent option for outpatient antimicrobial therapy programs due to its favorable safety profile and convenient once-weekly dosing. Ibrexafungerp has broad-spectrum antifungal activity, including activity against fluconazole- and echinocandin-resistant

Indexed as

ATI2307BAL2062Candida aurisCandida glabrataechinocandinsfluconazole resistancefosmanogepixibrexafungerpinvasive candidiasismiltefosinerezafungin

Identifiers

PMID42003962
PMCPMC13089233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.