ArticleInternational journal of biological sciences2026
RUNX2 enhances vascular remodeling to promote endothelial proliferation in acute liver injury.
Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: The liver has a unique capacity for self-renewal, maintaining a proper liver-to-bodyweight ratio, which is essential for sustaining homeostasis. Regenerative process in the liver involves intricate communication between various cell types such as hepatocytes, hepatic stellate cells, endothelial cells, and inflammatory cells. Although the role of endothelial cells in liver regeneration has been extensively studied, detailed knowledge regarding specific endothelial cell-derived factors that promote the regeneration of liver endothelial cells (LECs) remains limited. This study aimed to identify the regenerative capacity of endothelial progenitor cells (EPCs) after acute liver injury. Methods: Thioacetamide (TAA) was used to induce acute liver injury. Bulk and single-cell RNA sequencing were analyzed to investigate changes in endothelial cells after TAA injection. Results: TAA resulted in the delamination of LECs, which exhibited the highest regenerative capacity after three days of TAA injection. TAA increased the number of EPCs and RUNX2 was significantly enriched in the EPC population. Endothelial RUNX2 promotes regeneration by regulating its target genes such as Conclusion: These findings provide novel insights into the intricate mechanisms regulating LEC regeneration and highlight the pivotal role played by RUNX2 in vascular remodeling.
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