ArticleInternational journal of biological sciences2026
Multi-Omics Profiling of Long Noncoding RNAs in Clear Cell Renal Cell Carcinoma for Characterization and Clinical Applications.
Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Clear cell renal cell carcinoma (ccRCC), the most common and lethal subtype of renal cell carcinoma, exhibits marked intratumoral heterogeneity and complicates clinical management. Although long noncoding RNAs (lncRNAs) regulate diverse cellular processes, their landscape and biomarker potential in ccRCC remain poorly defined. Here we performed single-nucleus and bulk transcriptomic, proteomic, and metabolomic analyses on a cohort of 100 ccRCC patients. The expression pattern of lncRNAs were described based on metacells. Malignant cells displayed broader but lower lncRNA expression, likely reflecting copy number alterations, whereas low-abundance lncRNAs in normal epithelial cells showed individual variability. Multi-omics integration was used to establish a preliminary lncRNA functional inference pipeline, identifying lncRNAs involved in metabolic and immune processes and validating their roles through functional and
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