Evidence map›Paper›PMID 42003915›Full record

ArticleInternational journal of biological sciences2026

Polycystin-1 Orchestrates Tumor Context-Dependent Mechanotransduction Programs Driving Epithelial-to-Mesenchymal Transition and Invasion in Solid Cancers.

Antonios N Gargalionis, Kostas A Papavassiliou, Angeliki-Ioanna Giannopoulou, Panagiotis Sarantis, Christina Piperi, Eleftheria Lakiotaki, Anastasios Stofas, Christos Adamopoulos, Panagiota Kontou, Efstathios Boviatsis and 5 more

Abstract read
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In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Antonios N GargalionisDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Kostas A PapavassiliouFirst University Department of Respiratory Medicine, 'Sotiria' Chest Hospital, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Angeliki-Ioanna GiannopoulouDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Panagiotis SarantisDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Christina PiperiDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Eleftheria LakiotakiFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Anastasios StofasFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Christos AdamopoulosDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Panagiota KontouDepartment of Mathematics, University of Thessaly, Lamia 35131, Greece.
Efstathios BoviatsisSecond Department of Neurosurgery, 'Attikon' University Hospital, Medical School, National and Kapodistrian University of Athens, Athens 12642, Greece.
Stefanos KorfiasFirst Department of Neurosurgery, 'Evaggelismos' General Hospital, Medical School, National and Kapodistrian University of Athens, Athens 10676, Greece.
Nikolaos KavantzasFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Penelope KorkolopoulouFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Efthimia K BasdraDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.
Athanasios G PapavassiliouDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanotransduction critically shapes tumor progression by regulating cytoskeletal remodeling, epithelial-to-mesenchymal transition (EMT), invasion, and immune evasion. Polycystin-1 (PC1) and polycystin-2 (PC2), established mechanosensitive proteins in epithelial systems, have recently been implicated in tumor biology; however, their roles across diverse solid malignancies remain insufficiently defined. We assessed PC1 and PC2 expression patterns and their associations with clinicopathological features in human lung, breast, prostate, and brain tumors. PC1 functional modulation was performed in xenograft models using an extracellular mechanosensitivity-blocking antibody, and in cancer cell lines via

Indexed as

Epithelial-Mesenchymal TransitionMechanotransduction, CellularNeoplasmsTRPP Cation ChannelsAnimalsCell Line, TumorCell MovementFemaleHumansMaleMiceNeoplasm InvasivenessProstatic NeoplasmsTRPP Cation Channelsepithelial-to-mesenchymal transition (EMT)mechanotransductionpolycystin-1polycystin-2solid malignanciestranscriptional coactivator with PDZ-binding motif (TAZ)

Identifiers

PMID42003915
PMCPMC13086009

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.