ArticleInternational journal of biological sciences2026
Loss of Frmd5 Inhibits Jak2-Stat3 Signalling Pathway and Impairs Cell Apoptosis During Vagina Luminal Formation in Puberty Mice.
Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
FRMD5, FERM-domain protein 5, has been reported to be associated with tumors progession and neurodevelopment, however its molecular mechanisms in normal cells and its functions during urinary epithelium development remain unknown. In this study, we identified that Frmd5 interacts with Jak2 and Stat3, leading to the enhanced Jak2/Stat3 complex formation and subsquently promoting phosphorylation of Stat3. In a urinary epithelium specific knockout of
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