Evidence map›Paper›PMID 42003910›Full record

ArticleInternational journal of biological sciences2026

TIM-4

Youyong Tang, Qiyuan An, Keying Zhang, Chenxin Liu, Riqing Wei, Ru Li, Zhiqing Wang, Sixiao He, Fudi Wang, Li Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Youyong TangDepartment of Clinical Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong, China.
Qiyuan AnDepartment of Biopharmaceutics, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.
Keying ZhangDepartment of Biopharmaceutics, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.
Chenxin LiuDepartment of Biopharmaceutics, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.
Riqing WeiDepartment of Biopharmaceutics, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.
Ru LiDepartment of Biopharmaceutics, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.
Zhiqing WangHenan Red Cross Blood Center, Zhengzhou, 450004, China.
Sixiao HeSchool of Medicine, The Chinese University of Hong Kong, Shenzhen, 518172, China.
Fudi WangThe Second Affiliated Hospital, School of Public Health, State Key Laboratory of Experimental Hematology, Zhejiang University School of Medicine, Hangzhou 310058, China.
Li MaInstitute of Molecular Immunology, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China.
Qiang MaDepartment of Biopharmaceutics, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle resident tissue macrophages (smRTMs) are strategically positioned to sense myofiber injury and coordinate inflammatory responses, but their mechanistic contribution to exertional heatstroke (EHS)-associated rhabdomyolysis (RM) remains poorly defined. Here, we delineate a ferroptosis-dependent pathway in smRTMs that drives RM during EHS. Using mouse model of EHS, in combination with single-cell RNA sequencing, smRTM-targeted

Indexed as

FerroptosisHeat StrokeMacrophagesMembrane ProteinsMuscle, SkeletalRhabdomyolysisAnimalsHeme Oxygenase-1InflammasomesLipid PeroxidationMiceMice, Inbred C57BLNLR Family, Pyrin Domain-Containing 3 ProteinHeme Oxygenase-1InflammasomesMembrane ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinTIM-4 protein, mouseFerroptosisNOD-like receptor family pyrin domain containing 3olfactory receptor 2Rhabdomyolysis.T cell membrane protein 4-positive skeletal muscle resident tissue macrophages

Identifiers

PMID42003910
PMCPMC13085888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.