Evidence map›Paper›PMID 42003899›Full record

ArticleInternational journal of biological sciences2026

Monocyte Preprogramming by Tobacco Carcinogens and Fructose Intake Accelerates Lung Cancer Progression via Metabolic and Epigenetic Pathways.

Jee Hwan Ahn, Hye-Young Min, Jisung Kim, Xuan Wei, Namwon Kim, Ho-Young Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jee Hwan AhnDepartment of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Hye-Young MinNatural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Jisung KimCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Xuan WeiCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Namwon KimCollege of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Ho-Young LeeNatural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although tobacco smoking is the leading cause of lung cancer (LC), excessive sugar intake has also emerged as a potential risk factor, yet its mechanistic contribution remains poorly defined. In this study, we investigated how high-fructose intake modulates the tobacco carcinogen-induced LC progression. Co-exposure to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and benzo[a]pyrene (NNK and BaP; collectively referred to as NB) combined with a high-fructose diet markedly accelerated tumor progression in multiple mouse models, including Kras

Indexed as

CarcinogensFructoseLung NeoplasmsMonocytesAnimalsBenzo(a)pyreneEpigenesis, GeneticHumansMacrophagesMiceNitrosaminesBenzo(a)pyreneCarcinogensFructoseNitrosaminescancer progressionfructosemetabolic reprogrammingnon-small cell lung cancertobacco carcinogens

Identifiers

PMID42003899
PMCPMC13086078

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.