Evidence map›Paper›PMID 42003868›Full record

ReviewInternational journal of cardiology. Cardiovascular risk and prevention2026

Prognostic significance of carotid intima-media thickness in patients with coronary slow flow: A systematic review and meta-analysis.

Akhil Kumar Sharma, Ayush Shukla, Gaurav Chaudhary, Sharad Chandra, Umesh Chandra Tripathi, Safal Safal, Satyavir Yadav, Awadhesh Kumar Sharma

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of cardiology. Cardiovascular risk and prevention, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Akhil Kumar SharmaKing George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Ayush ShuklaKing George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Gaurav ChaudharyKing George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Sharad ChandraKing George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Umesh Chandra TripathiKing George's Medical University, Lucknow, Uttar Pradesh, 226003, India.
Safal SafalDepartment of Cardiology, MAMC and G.B. Pant Institute of Postgraduate Medical Education and Research, Delhi, India.
Satyavir YadavDepartment of Cardiology AIIMS New Delhi, Delhi, India.
Awadhesh Kumar SharmaDepartment of Cardiology, LPS Institute of Cardiology, G.S.V.M. Medical College Kanpur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Carotid intima-media thickness (CIMT), a marker of systemic atherosclerosis, has been proposed as a prognostic marker of coronary slow flow (SCF). This systematic review and meta-analysis was performed to evaluate the predictive outcomes of CIMT in SCF patients compared to patients with normal coronary flow (NCF). Methods: This systematic review, conducted according to PRISMA and a pre-specified PECOS protocol, systematically searched PubMed/MEDLINE, Embase, Scopus, Web of Science, Cochrane Library, and Google Scholar for observational studies (cohort, case-control, cross-sectional) comparing CIMT and TIMI frame count (TFC) in SCF versus NCF patients. Two reviewers independently extracted data and assessed methodological quality using ROBINS-I and AXIS. A random-effects model estimated mean differences (MD) in CIMT and TFC, with heterogeneity evaluated by the I Results: Eight studies involving 451 SCF patients and 344 NCF controls were included. CIMT was significantly higher in SCF patients (pooled MD -0.14 mm; 95% CI -0.21 to -0.07; I Conclusion: The association of slow coronary flow with increased carotid intima-media thickness supports its role as a marker of systemic subclinical atherosclerosis and highlights CIMT as a potential non-invasive tool for early risk stratification.

Indexed as

Carotid intima-media thicknessCoronary slow flowMeta-analysisPrognosisSystematic reviewTIMI frame count

Identifiers

PMID42003868
PMCPMC13091223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.