ArticleJournal of the American Heart Association2026
Plasma von Willebrand Factor and ADAMTS13 Interact With
Hailey A Adegboye, Yunyi Sun, Panpan Zhang, Dandan Liu, Omair A Khan, Kahraman Tanriverdi, Antonina Risitano, Julia Libby, Khiry L Patterson, Albert B Arul and 13 more
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In one paragraphArticle in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
23 authors.
Hailey A AdegboyeVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.
Yunyi SunVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.
Panpan ZhangVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0002-8211-5930 Dandan LiuVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0002-7176-8346 Antonina RisitanoDepartment of Medicine Vanderbilt University Medical Center Nashville TN USA.
Julia LibbyVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.
Khiry L PattersonVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.
Albert B ArulDepartment of Chemistry Vanderbilt University Nashville TN USA.
Vaibhav A JanveVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0001-8587-3676 Logan C DumitrescuVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0002-9782-9944 Kimberly R PechmanVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0003-0596-8064 Niranjana ShashikumarVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0009-0006-5627-8281 Corey J BoltonVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0002-1715-5370 L Taylor DavisVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.
Bennett A LandmanVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0001-5733-2127 Renã A S RobinsonVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0001-6307-8671 Timothy J HohmanVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0002-3377-7014 Angela L JeffersonVanderbilt Memory and Alzheimer's Center Vanderbilt University School of Medicine Nashville TN USA.ORCID 0000-0002-8245-0587 Funding
Sex-Specific Genetic Drivers of Alzheimer's Disease EndophenotypesR01AG073439 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Logan C Dumitrescu · 2021 to 2026
$4.8MNIA NIH HHS R01 AG073439
6 · The paper itselfAbstract
backgroundVon Willebrand factor (VWF) and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) are linked to dementia risk, and limited evidence suggests
methodsVanderbilt Memory and Aging Project cohort participants (n=332, 73±7 years, 59% male) completed serial blood draw, neuropsychological assessment, and brain magnetic resonance imaging over 6.4 years (range 1.4-9.7 years). Baseline plasma VWF and ADAMTS13 levels were quantified using mass spectrometry and Olink. Fully adjusted linear mixed-effects models related
resultsLower baseline ADAMTS13 predicted faster declines in language (β=0.11,
conclusionsADAMTS13 shows promise as a potential plasma biomarker for brain aging outcomes, but additional research is warranted to understand the performance of VWF in the presence versus absence of an
Indexed as
ADAMTS13 ProteinApolipoprotein E4BrainCognitionCognition DisordersCognitive Dysfunctionvon Willebrand FactorAgedAged, 80 and overAtrophyBiomarkersFemaleFollow-Up StudiesHumansLongitudinal StudiesMagnetic Resonance ImagingADAMTS13 ProteinADAMTS13 protein, humanApolipoprotein E4Biomarkersvon Willebrand FactorADAMTS13apolipoprotein E‐ε4cognitionneuroimagingvon Willebrand factor
Identifiers
PMID42003668
PMCPMC13279195
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