Evidence map›Paper›PMID 42003614›Full record

ArticlemBio2026

Vacuolar iron export alters the synergy between doxycycline and fluconazole by affecting cidal ROS levels in

Wouter Van Genechten, Michelle Holtappels, Martine De Jonge, Rudy Vergauwen, Gauthier Cornips, Patrick Van Dijck

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wouter Van GenechtenLaboratory for Molecular Cell Biology, Department Biology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-8562-8029
Michelle HoltappelsLaboratory for Molecular Cell Biology, Department Biology, KU Leuven, Leuven, Belgium.
Martine De JongeLaboratory for Molecular Cell Biology, Department Biology, KU Leuven, Leuven, Belgium.
Rudy VergauwenLaboratory for Molecular Cell Biology, Department Biology, KU Leuven, Leuven, Belgium.
Gauthier CornipsLaboratory for Molecular Cell Biology, Department Biology, KU Leuven, Leuven, Belgium.
Patrick Van DijckLaboratory for Molecular Cell Biology, Department Biology, KU Leuven, Leuven, Belgium.ORCID 0000-0002-1542-897X

Funding

Onderzoeksraad, KU Leuven C14/22/075
6 · The paper itself

Abstract

Fungal infections are combatted using three main classes of antifungals, of which the azoles, considered to be fungistatic, are the most widely used. Slow growth of

Indexed as

Antifungal AgentsCandida albicansDoxycyclineFluconazoleIronReactive Oxygen SpeciesVacuolesDrug SynergismFungal ProteinsMicrobial Sensitivity TestsMitochondriaAntifungal AgentsDoxycyclineFluconazoleFungal ProteinsIronReactive Oxygen Speciesantifungal therapyCandida albicansdoxycyclinefluconazoleiron regulationiron transportmitochondrial metabolismvacuoles

Identifiers

PMID42003614
PMCPMC13170289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.