Observational studyJournal of the American Heart Association2026
Incident Atrial Fibrillation and Flutter in Patients With Pulmonary Arterial Hypertension: Influence of Right Ventricular Dilatation and Reduced Right Atrial Function.
Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Beyond the right ventricle: left heart involvement in pulmonary arterial hypertension.Heart failure reviews · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between right atrial (RA) structural and functional remodeling and risk of incident atrial fibrillation/flutter (AF/AFL) in pulmonary arterial hypertension remains poorly defined.
methodsIn a multicenter observational cohort study of 326 patients with pulmonary arterial hypertension, we evaluated associations between RA structure and function, as determined by echocardiography, and incident AF/AFL. Incidence rates were calculated using time-to-event analysis. Cox proportional hazards models identified factors associated with incident AF/AFL, and Harrell's C-statistics compared predictive performance. Survival decision tree and restricted cubic spline analyses identified thresholds associated with increased risk of AF/AFL.
resultsThe mean age was 51±15 years, 79% were women, and the mean REVEAL (Registry to Evaluate Early and Long-Term Outcomes in Pulmonary Arterial Hypertension) Lite score was 7.4±2.9. Over a median follow-up of 6.1 years, 56 patients (17.1%) developed AF/AFL, corresponding to an incidence rate of 25.3 cases (95% CI, 19.5-32.8) per 1000 person-years. Each 5% decrease in RA emptying fraction (hazard ratio [HR], 1.38 [95% CI, 1.03-1.86];
conclusionsLarger right ventricular basal diameter and lower RA emptying fraction are associated with increased risk of incident AF/AFL in patients with pulmonary arterial hypertension and may help identify individuals at higher risk.
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