ArticleMicrobiology spectrum2026
Prevalence of vaginal microecological disorder and its association with HPV infections in pregnant women attending prenatal examinations.
Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Vaginal infections are closely associated with human papillomavirus (HPV) infection, yet research on vaginal microecology and HPV mRNA expression in pregnant women remains limited. This study aimed to explore the prevalence of vaginal microecological disorders and their relationship with HPV infection among pregnant women. A cross-sectional study was conducted involving 630 pregnant women who received prenatal care at Fujian Maternity and Child Health Hospital from 2023 to 2024. All participants underwent both the Aptima HPV E6/E7 mRNA assay and vaginal microecological examinations. Clinical characteristics, virological results, and vaginal microecological alterations were analyzed. Of the 630 participants, 241 (38.3%) exhibited vaginal microecology disorders, with aerobic vaginitis (AV, 12.7%) being the most common subtype. A total of 97 (15.4%) participants had received HPV vaccination. The overall high-risk (HR)-HPV E6/E7 mRNA positivity rate was 28.6 % , including 4.8 % for HPV16/18/45 and 23.8 % for the other 11 high-risk genotypes. Age-adjusted multivariate logistic regression analysis identified the following independent risk factors for HR-HPV E6/E7 mRNA positivity: bacterial vaginosis (BV) (aOR = 2.42, 95% CI = 1.25-4.70,
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