Evidence map›Paper›PMID 42003581›Full record

ArticleAntimicrobial agents and chemotherapy2026

Mass balance study of [

Chun-Yang Zhao, Gang-Yi Liu, Lin Qian, Yu-Lei Zhuang, Lin Luo, Ying-Jun Zhang, Hong-Ming Xie, Jing Zhu, Ming Li, Qian Chen and 3 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chun-Yang Zhao *Drug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-3617-5983
Gang-Yi Liu *Drug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai, China.
Lin QianDrug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai, China.
Yu-Lei ZhuangSunshine Lake Pharma Co., Ltd., Guangdong, China.
Lin LuoSunshine Lake Pharma Co., Ltd., Guangdong, China.
Ying-Jun ZhangSunshine Lake Pharma Co., Ltd., Guangdong, China.
Hong-Ming XieSunshine Lake Pharma Co., Ltd., Guangdong, China.
Jing ZhuSunshine Lake Pharma Co., Ltd., Guangdong, China.
Ming LiSunshine Lake Pharma Co., Ltd., Guangdong, China.
Qian ChenDrug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai, China.
Yun LiuDrug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai, China.
Jing-Ying JiaDrug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-2492-3219
Yan-Mei LiuDrug Clinical Trial Center, Shanghai Xuhui Central Hospital/Xuhui Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-1174-8447

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Netanasvir Phosphate is a novel second-generation NS5A inhibitor used for the treatment of chronic hepatitis C virus (HCV) infection. This study investigated the absorption, distribution, metabolism, and excretion (ADME), and the metabolite profile of [¹⁴C]Netanasvir Phosphate. In a single-dose, open-label study, six healthy Chinese male volunteers received an oral dose of 100 mg/200 µCi of [¹⁴C]Netanasvir Phosphate under fed conditions. Blood, urine, and fecal samples were collected for up to 336 h post-dose. Total radioactivity was measured using oxidative combustion and liquid scintillation counting, and the parent drug and its metabolites were analyzed by validated liquid chromatography-tandem mass spectrometry and low-energy radiometric detection and mass spectrometry methods. The pharmacokinetic profile showed a median

Indexed as

Antiviral AgentsAdministration, OralAdultCarbon RadioisotopesEast Asian PeopleFecesHealthy VolunteersHumansMaleTandem Mass SpectrometryYoung AdultAntiviral AgentsCarbon-14Carbon Radioisotopesabsorptiondistributionmass balancemetabolismmetabolitespharmacokineticssafety

Identifiers

PMID42003581
PMCPMC13231878

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.