In one paragraphArticle in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
19 authors.
Mélanie Bazin-GélisUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0001-5670-1453 Marc GuérineauUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0002-0546-3106 Valerio VitaliUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0003-3593-1510 Coralie ZangarelliUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0002-1645-3210 Olivier ArnaizUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0002-9626-1015 Louise AbbouUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris 75013, France.
Abdulwahab AltairUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.
Aménaïde Boutte du JonchayUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.
Aurélie CamprodonUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.
Marina GiovannettiUniversité Paris Cité, CNRS, Institut Jacques Monod, Paris 75013, France.
Camille PoitrenaudUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.
Emma SchumacherUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.
Julien BischerourUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0002-5254-3395 Anne-Marie TassinUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0002-6083-9460 Vinciane RégnierUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0002-2601-553X Mireille BétermierUniversité Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette 91198, France.ORCID 0000-0002-5407-6292 Funding
Agence Nationale pour la Recherche ANR-19-CE12-0015Agence Nationale pour la Recherche ANR-21-CE12-0019Agence Nationale pour la Recherche ANR-23-CE12-0027Agence Nationale pour la Recherche ANR-25-CE12-7757Centre National de la Recherche ScientifiqueEUR GENE ANR-17-EURE-0013Fondation pour la Recherche Médicale FRM EQU202103012766Fondation pour la Recherche Médicale FRM EQU202203014643French Infrastructure for Integrated Structural Biology ANR-10-INBS-0005Institute for Integrative Biology of the Cell FDT202404018139
6 · The paper itselfAbstract
Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium, elimination of transposable elements and their relics requires the PiggyMac (Pgm) endonuclease and its five PgmL partners, yet how this machinery is targeted to cleavage sites remains unclear. Here, we identified condensin I subunits in the proximity proteomes of Pgm and PgmL4. We show that they belong to a condensin complex that is essential for PDE and localizes to developing somatic nuclei. Depleting the development-specific subunits of this complex blocks DNA elimination, phenocopying a Pgm depletion. Developmental condensin is required for the correct nuclear localization of Pgm and some of the PgmLs. Moreover, Pgm and these PgmLs coimmunoprecipitate with condensin I. Our findings uncover functional and physical interactions between a eukaryotic DNA cleavage machinery and a specialized condensin complex that is critical for PDE in a nondividing nucleus.
Indexed as
Adenosine TriphosphatasesDNA-Binding ProteinsMultiprotein ComplexesParameciumProtozoan ProteinsTransposasesCell NucleusDNA CleavageProtein SubunitsAdenosine Triphosphatasescondensin complexesDNA-Binding ProteinsMultiprotein ComplexesProtein SubunitsProtozoan ProteinsTransposases
Identifiers
PMID42003548
PMCPMC13092971
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390