Evidence map›Paper›PMID 42003465›Full record

ArticleCirculation research2026

Exercise Metabolic Memory Halts Pathological Cardiac Hypertrophy via PDK4.

Cankun Zheng, Xiaoxia Huang, Xinnan Wei, Changzhu Liang, Lu Chen, Mingjue Li, Rui Zhang, Mingyuan He, Zhihong Li, Rongzhan Lin and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Cankun ZhengDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0002-0815-646X
Xiaoxia HuangCardiovascular Centre (X.H., M.L., M.S., J.B., Y.L.), the Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou.
Xinnan WeiDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).
Changzhu LiangDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).
Lu ChenDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0003-4482-7600
Mingjue LiDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0001-7613-568X
Rui ZhangDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).
Mingyuan HeDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0002-1146-616X
Zhihong LiDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).
Rongzhan LinDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0001-6652-6839
Mengjia ShenCardiovascular Centre (X.H., M.L., M.S., J.B., Y.L.), the Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou.ORCID 0000-0003-1748-3726
Jichen LiuDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0002-4447-7367
Qiancheng WangDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).
Jianhua HuangKey Laboratory of Surgery of Liaoning Province, First Affiliated Hospital of Jinzhou Medical University, China (J.H.).
Wangjun LiaoDepartment of Oncology (W.L.), the Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou.
Jianping BinCardiovascular Centre (X.H., M.L., M.S., J.B., Y.L.), the Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou.ORCID 0000-0003-4799-1502
Hairuo LinDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0003-0413-3807
Yulin LiaoDepartment of Cardiology, State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Nanfang Hospital, Southern Medical University, Guangzhou, China (C.Z., X.W., C.L., L.C., M.L., R.Z., M.H., Z.L., R.L., J.L., Q.W., H.L., Y.L.).ORCID 0000-0001-5961-390X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPathological cardiac hypertrophy remains a major contributor to heart failure, with impaired glucose metabolism playing a central role. Although exercise is known to enhance myocardial glucose utilization, the long-term metabolic reprogramming effects of exercise and their role in preventing pathological hypertrophy are poorly understood. This study elucidates the mechanisms underlying the sustained metabolic memory induced by exercise-induced hypertrophic preconditioning (EHP) and its cardioprotective effects, with a focus on RNA methylation and arachidonic acid metabolism.

methodsWe used positron emission tomography/computed tomography to assess cardiac glucose uptake and bulk RNA sequencing to profile myocardial gene expression in sedentary and EHP mice. Genetic manipulation of

resultsEHP conferred sustained myocardial glucose preference even after regression of physiological hypertrophy, mediated through METTL3 (methyltransferase-like 3)-dependent m6A RNA methylation that suppressed

conclusionsThis study establishes a unified mechanism by which EHP induces metabolic memory through RNA methylation-dependent suppression of

Indexed as

CardiomegalyCardiomegaly, Exercise-InducedEnergy MetabolismPhysical Conditioning, AnimalPyruvate Dehydrogenase Acetyl-Transferring KinaseAnimalsArachidonic AcidCells, CulturedGlucoseMaleMiceMice, Inbred C57BLMice, KnockoutMyocytes, CardiacRatsRNA MethylationArachidonic AcidGlucosePdk4 protein, mousePyruvate Dehydrogenase Acetyl-Transferring Kinasearachidonic acidexercisefibrosisglucoseRNA methylation

Identifiers

PMID42003465
PMCPMC13189389

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