Evidence map›Paper›PMID 42003363›Full record

ArticleJournal of diabetes research2026

Mechanism of Platelet-Rich Plasma in Promoting Diabetic Wound Healing via the PI3K/AKT Signaling Pathway to Regulate Collagen Synthesis and Angiogenesis.

Hongyan Liu, Wenzhen Huang, Shuting Jiang, Beizhan Yan, Cunquan Kong, Weiyan Zhu, Qi Xie, Cuiyun Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongyan LiuDepartment of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0009-0007-8755-8603
Wenzhen HuangDepartment of Endocrinology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0000-0002-7847-9862
Shuting JiangDepartment of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0009-0008-6209-8548
Beizhan YanDepartment of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0009-0001-0300-474X
Cunquan KongDepartment of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0009-0009-2256-0213
Weiyan ZhuDepartment of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0009-0000-1149-6054
Qi XieDepartment of Pathology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0000-0003-4093-0563
Cuiyun CuiDepartment of Transfusion Medicine, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China, zzu.edu.cn.ORCID https://orcid.org/0009-0004-2160-3043

Funding

National Natural Science Foundation of China 82203363
6 · The paper itself

Abstract

Platelet-rich plasma (PRP) has been found effective in wound healing, yet the underlying mechanisms in the healing of diabetic wounds remain unclear. In this study, we focus on investigating the role of PRP in enhancing the wound healing in a diabetic mouse model, specially through the modulation of the PI3K/AKT signaling pathway and its effect on collagen production and angiogenesis in the wounds of diabetic mouse model. In our in vitro experiments, we observed that PRP, in a concentration-dependent manner, significantly stimulated the proliferation, migration, and collagen synthesis in human dermal fibroblasts. Concurrently, PRP activated the PI3K/AKT and TGF-β/SMAD2 signaling pathways. In vivo, utilizing a diabetic mouse model of wound healing, PRP treatment significantly enhanced wound healing by accelerating wound closure, improving collagen deposition and organization, and promoting angiogenesis, as evidenced by increased expression of CD31 and VEGF. Importantly, the application of the PI3K inhibitor LY294002 effectively inhibited the observed effects of PRP. Additionally, the activation of the TGF-β/SMAD2 signaling pathway induced by PRP was also suppressed when PI3K was inhibited, suggesting that the PI3K/AKT pathway functions upstream to regulate TGF-β/SMAD2 signaling. These findings elucidate the role of PRP in facilitating diabetic wound healing through the activation of the PI3K/AKT pathway, which subsequently cross-regulates TGF-β/SMAD2 signaling, thereby enhancing cellular functions vital for tissue regeneration. Our results contribute valuable mechanistic insights into the therapeutic potential of PRP in addressing impaired wound healing in diabetic patients.

Indexed as

AngiogenesisCollagenDiabetes Mellitus, ExperimentalNeovascularization, PhysiologicPhosphatidylinositol 3-KinasesPlatelet-Rich PlasmaProto-Oncogene Proteins c-aktWound HealingAnimalsCell MovementCell ProliferationFibroblastsHumansMaleMiceMice, Inbred C57BLCollagenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSmad2 ProteinTransforming Growth Factor betaangiogenesisdiabetic wound healingfibroblast proliferationPI3K/AKT signaling pathwayplatelet-rich plasma (PRP)TGF-β/SMAD2 signaling

Identifiers

PMID42003363
PMCPMC13093075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.