Evidence map›Paper›PMID 42003321›Full record

SynthesisAnnals of medicine2026

Comparative evaluation of oxidative stress biomarkers F2-isoprostanes and 8-OHdG in Parkinson's disease and Type 2 Diabetes Mellitus: a systematic review and meta-analysis of human studies.

Samwel Sylvester Msigwa, Maiko Charles Mkwambe, Qiu-Yan Yu, Shi-Guo Zhu, Jian-Hong Zhu, Xiong Zhang, Jian-Yong Wang

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samwel Sylvester MsigwaDepartment of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Maiko Charles MkwambeDepartment of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China.
Qiu-Yan YuDepartment of Epidemiology and Statistics, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shi-Guo ZhuDepartment of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0002-3439-2319
Jian-Hong ZhuInstitute of Nutrition and Diseases and Center for Research, School of Public Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0001-9412-8264
Xiong ZhangDepartment of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jian-Yong WangDepartment of Neurology, Institute of Geriatric Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.ORCID 0000-0003-4695-4806

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxidative stress is central to type 2 diabetes mellitus (T2DM) and Parkinson's disease (PD). However, the utility of biomarkers for lipid peroxidation (F2-isoprostanes) and DNA damage (8-OHdG) in the comorbidity of PD and T2DM remains unclear.

methodsWe conducted a systematic review and meta-analysis of 54 unique studies of human subjects aged ≥ 50 years (

resultsIn T2DM, F2-isoprostanes (

conclusionDistinct profiles - both markers elevated in T2DM but only 8-OHdG in PD - underscore 8-OHdG's potential in PD-T2DM comorbidity. Future research should focus on standardized assays, multi-compartmental or multi-modal sampling, and longitudinal studies to clarify mechanisms and therapeutic targets.

Indexed as

DeoxyguanosineDiabetes Mellitus, Type 2F2-IsoprostanesOxidative StressParkinson Disease8-Hydroxy-2'-DeoxyguanosineBiomarkersDNA DamageHumansLipid PeroxidationMiddle Aged8-Hydroxy-2'-DeoxyguanosineBiomarkersDeoxyguanosineF2-Isoprostanes8-OHdGcomorbiditydiabetesF2-isoprostanesOxidative stressParkinson’s disease

Identifiers

PMID42003321
PMCPMC13097182

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.