ArticleAnnals of medicine2026
No independent association between lymph node metastasis location and recurrence in papillary thyroid carcinoma: a long-term study.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWhether lymph node metastasis in different anatomical regions of papillary thyroid carcinoma affects recurrence-free survival is controversial. This long-term follow-up study aims to evaluate the impact of lymph node metastasis region on recurrence-free survival and identify independent recurrence factors. MATERIALS AND
methodsThis cross-sectional study included 1,378 patients who underwent at least unilateral thyroid lobectomy plus central and lateral lymph node dissection. Propensity score matching, Cox proportional hazards regression, and time-dependent receiver operating characteristic curve analysis were performed to assess recurrence-free survival, recurrence predictors, and predictive accuracy.
resultsAmong 1,378 patients, isolated central, lateral, and combined lymph node metastasis occurred in 361 (26.2%), 75 (5.4%), 584 (42.4%), respectively. With 91-month median follow-up, 43 (3.1%) developed recurrence. Prior to matching, patients with lateral lymph node metastasis demonstrated significantly poorer recurrence-free survival compared to those without lateral nodal involvement (
conclusionsThe anatomical region of lymph node metastasis was not an independent risk factor for recurrence free survival in papillary thyroid carcinoma patients. Male, clinically lymph node positive, and lymph node metastasis ratio > 26.3% were independent recurrence risk factors. For patients with high-risk recurrence factors, close clinical surveillance should be considered.
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