Trial reportJournal of cosmetic dermatology2026
Comparison of Compound Lidocaine Cream and Lidocaine-Prilocaine Cream for Pain Management in Facial Rejuvenation: A Randomized Controlled Trial.
Trial report in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
backgroundEffective pain management is essential for enhancing patient satisfaction and treatment compliance during facial rejuvenation procedures. Compound lidocaine cream and lidocaine-prilocaine cream are commonly used topical anesthetics in clinical practice; however, high-quality randomized controlled trials directly comparing their analgesic efficacy and safety in facial rejuvenation remain limited.
objectiveThis study aimed to compare the analgesic efficacy and safety of compound lidocaine cream and lidocaine-prilocaine cream in patients undergoing facial rejuvenation procedures.
methodsThis single-center, prospective, randomized controlled trial enrolled 100 patients undergoing facial rejuvenation between January 2024 and June 2025. Participants were randomly assigned to receive either compound lidocaine cream (n = 47) or lidocaine-prilocaine cream (n = 53). The primary outcome was procedural pain intensity, assessed using a 10-point visual analog scale (VAS). Secondary outcomes included the incidence of adverse reactions, patient satisfaction, and treatment compliance.
resultsBaseline characteristics were comparable between the two groups (p > 0.05). The mean pain score was significantly lower in the compound lidocaine cream group than in the lidocaine-prilocaine cream group (2.51 ± 1.80 vs. 3.75 ± 1.74; t = -3.48, p < 0.001). Adverse reactions occurred in 4.3% (2/47) of patients in the compound lidocaine cream group and 11.3% (6/53) in the lidocaine-prilocaine cream group, with no statistically significant difference between groups (χ
conclusionCompound lidocaine cream demonstrated superior analgesic efficacy in this clinical comparison; however, differences in anesthetic concentration, application technique, and lack of participant blinding should be considered when interpreting these findings. Larger studies with standardized dosing and blinding are warranted.
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