ArticleJournal of biochemical and molecular toxicology2026
Octreotide Counteracts IFN-γ-Induced Endothelial Inflammation.
Article in Journal of biochemical and molecular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Activating transcription factor 6 is involved in the beneficial effects of growth hormone-releasing hormone antagonists in the corneal endothelium.Frontiers in ophthalmology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Endothelial cells maintain vascular homeostasis through the regulation of permeability and coagulation. Interferon-gamma (IFN-γ), a proinflammatory cytokine released by activated T lymphocytes and natural killer cells, disrupts endothelial junctional integrity, leading to barrier dysfunction. Octreotide (OCT), a synthetic somatostatin analog (SSA), is used to suppress excessive growth hormone secretion and inhibits tumor growth. The present study investigates the potential anti-inflammatory and cytoprotective properties of OCT in IFN-γ-induced endothelial injury. Our observations suggest that OCT suppresses IFN-γ-induced activation of cofilin, MLC2, JAK2, STAT1, STAT3, and P38; as well as endothelial hyperpermeability and ROS generation. Hence, the study supports ongoing efforts aiming to substantiate the protective role of somatostatin analogs in endothelium-dependent disorders, including lung injury and sepsis.
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