Evidence map›Paper›PMID 42003090›Full record

ArticleJournal of clinical pharmacology2026

Population Pharmacokinetics and Exposure-Safety Analysis of Furosemide in Preterm Infants.

Rachel L Randell, Anil Maharaj, Matthew Laughon, Chi D Hornik, Rachel G Greenberg, Jason E Lang, Michael Cohen-Wolkowiez, Christoph P Hornik, Ravinder Anand, Karen Martz and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Rachel L RandellDepartment of Pediatrics, Duke University, Durham, NC, USA.ORCID 0000-0002-8009-8209
Anil MaharajDuke Clinical Research Institute, Durham, NC, USA.
Matthew LaughonDepartment of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Chi D HornikDepartment of Pediatrics, Duke University, Durham, NC, USA.
Rachel G GreenbergDepartment of Pediatrics, Duke University, Durham, NC, USA.
Jason E LangDepartment of Pediatrics, Duke University, Durham, NC, USA.ORCID 0000-0001-9115-5312
Michael Cohen-WolkowiezDepartment of Pediatrics, Duke University, Durham, NC, USA.
Christoph P HornikDepartment of Pediatrics, Duke University, Durham, NC, USA.
Ravinder AnandThe Emmes Company, Rockville, MD.
Karen MartzThe Emmes Company, Rockville, MD.
Elizabeth H PayneThe Emmes Company, Rockville, MD.ORCID 0000-0003-0905-7647
Kevin WattDepartment of Pediatrics, University of Utah, Salt Lake City, UT, USA.
William J MullerAnn & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.ORCID 0000-0001-7690-0695
Sherry E CourtneyArkansas Children's Hospital, Little Rock, AR, USA.
Andrew AtzDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Amira Al-UzriDepartment of Pediatrics, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0001-6532-7117
Gregory M SokolDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Barry T BloomDepartment of Neonatology, Wesley Medical Center, Wichita, KS, USA.
Anjali IyengarDepartment of Pediatrics, Tufts Medical Center, Boston, MA, USA.
Mina HannaDepartment of Pediatrics, University of Kentucky College of Medicine, Lexington, KY, USA.
Daniel K BenjaminDepartment of Pediatrics, Duke University, Durham, NC, USA.
Stephen J BalevicDepartment of Pediatrics, Duke University, Durham, NC, USA.ORCID 0000-0002-4016-1680
Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee

Funding

NICHD NIH HHS HHSN267200700051CNICHD NIH HHS HHSN275201000003INICHD NIH HHS HHSN275201700002CNICHD NIH HHS HHSN275201800003I
6 · The paper itself

Abstract

Furosemide is the most commonly used diuretic in preterm infants despite an incompletely understood relationship between dosing, exposure, and safety within this population. The goals of this study were to characterize furosemide population pharmacokinetics (popPK) in preterm infants and to evaluate safety by relating simulated furosemide exposure to events of ototoxicity, nephrocalcinosis, and nephrolithiasis. A total of 146 plasma furosemide concentrations from 51 preterm (23-28.9 weeks' gestational age) infants across two studies (one randomized, placebo-controlled, dose-escalating safety trial and one opportunistic, observational study) were included in the analysis. Standard nonlinear mixed effects popPK modeling techniques were applied. Exposure was simulated using the final popPK model (area under the curve) and Monte Carlo simulations (maximum concentration [C

Indexed as

DiureticsFurosemideInfant, PrematureModels, BiologicalDose-Response Relationship, DrugFemaleHumansInfant, NewbornMaleMonte Carlo MethodNephrocalcinosisObservational Studies as TopicRandomized Controlled Trials as TopicDiureticsFurosemidediureticsfurosemideinfantneonatepharmacokineticspreterm infant

Identifiers

PMID42003090
PMCPMC13120744

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.