ArticlePest management science2026
Efficient control of Tribulium castaneum using zeolitic imidazolate framework-8 nanocarrier-mediated delivery of dsRNA targeting Paramyosin.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTribolium castaneum is a major pest that affects stored grains globally. RNA insecticides present a promising strategy for the management of insect pests; however, they encounter challenges in target gene discovery, cost and efficiency. The paramyosin (PM) gene has shown potential as a target for RNAi-based insecticides. This study aims to explore the potential of ZIF-8@dsTcPM complexes as an RNA insecticide, assessing their effectiveness in targeting the TcPM gene while ensuring stability and protection of dsRNA.
resultsThis study discovered that the PM gene exists throughoutthe life cycle of T. castaneum and is predominantly located in adult muscle tissues. The dsTcPM notably downregulated TcPM gene expression, causing high mortalities in larvae and adults. The PM gene was highly conserved across diverse insect orders but absent in vertebrates, suggesting that the RNA insecticides targeting this gene may offer broad-spectrum control of insect pests with mammalian safety. The L4440-HT115 produced functional dsTcPM efficiently (2.15 μg mL
conclusionThis work demonstrates that the ZIF-8@dsTcPM offers a promising option for the effective prevention and sustainable control of T. castaneum. © 2026 Society of Chemical Industry.
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