ArticleThe Journal of veterinary medical science2026
Assessment of selected nutritional, bone metabolic and stress-related biomarkers across the weaning transition in naturally suckled Japanese Black calves.
Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naturally suckled Japanese Black calves are vulnerable to nutritional decline around weaning due to low maternal milk yield and abrupt maternal separation. While plasma total cholesterol (TCHO) is a reliable indicator of energy balance, its role as a lagging indicator makes early detection of 'refractory' calves-those with delayed metabolic recovery-challenging. This study aimed to characterize nutritional, bone metabolic, and stress-related physiological changes during the weaning transition and to identify early predictors of post-weaning metabolic resilience. Twelve naturally suckled Japanese Black calves were monitored from two weeks before weaning to six weeks after weaning for multiple indicators: plasma total cholesterol (TCHO), beta-hydroxybutyrate (BHB), non-esterified fatty acid (NEFA), glucose (GLU), albumin (ALB), blood urea nitrogen (BUN), calcium (Ca), phosphorus (P), alkaline phosphatase 3 (ALP3), tartrate-resistant acid phosphatase 5b (TRAP5b), cortisol, and oxytocin. Calves were grouped into low and high TCHO groups based on plasma TCHO concentrations six weeks after weaning, and group differences and predictive performance were evaluated using mixed models and ROC analysis. Across all calves, plasma TCHO, NEFA, GLU, ALB, P, ALP3, and TRAP5b decreased after weaning, whereas stress-related biomarkers remained within reported physiological ranges and showed no clear weaning-associated surge. Pre-weaning salivary cortisol showed discriminative ability for subsequent refractory metabolic recovery (AUC=1.00). In conclusion, pre-weaning salivary cortisol serves as a sensitive indicator of 'metabolic readiness' to identify calves at risk for refractory recovery, facilitating proactive management to optimize growth and resilience in natural suckling systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.