SynthesisAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2026
Early Non-Invasive Detection of Arterial Stiffness Related to Endothelial Dysfunction in Apical Periodontitis Patients: A Systematic Review and Meta-Analysis.
Synthesis in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
This systematic review and meta-analysis evaluated the association between apical periodontitis (AP) and non-invasive markers of arterial stiffness, including carotid intima-media thickness (c-IMT), endothelial flow reserve (EFR), flow mediated dilatation (FMD), carotid plaques and aortic atherosclerotic burden (AAB) in systemically healthy individuals. PubMed/MEDLINE, Cochrane, Scopus and EMBASE were searched. Quality assessment was done using the Newcastle-Ottawa Scale. Six studies were selected, with two at low and four at moderate risk of bias. Five studies (two c-IMT; three EFR) underwent meta-analysis. Pooled analysis demonstrated that AP was significantly associated with increased c-IMT (mean difference: 0.16 mm; 95% CI: 0.02-0.30; p = 0.01) and reduced EFR (mean difference: -0.30; 95% CI: -0.43 to -0.16; p < 0.0001). Heterogeneity was high for c-IMT (I
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