Evidence map›Paper›PMID 42002804›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Imaging the later-life white matter pathologies of repetitive head impacts: A novel pattern revealed through T2 FLAIR MRI.

Jenna R Groh, Annalise E Miner, Mohamad J Alshikho, Chad Farris, Anna Cui, Erika Pettway, Jacob Labonte, Sydney Mosaheb, Yorghos Tripodis, Charles H Adler and 41 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

51 authors.

Jenna R GrohDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-1831-9314
Annalise E MinerDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Mohamad J AlshikhoTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Chad FarrisBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Anna CuiDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Erika PettwayDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Jacob LabonteDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Sydney MosahebDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Yorghos TripodisBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Charles H AdlerDepartment of Neurology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Laura J BalcerDepartment of Neurology, NYU Grossman School of Medicine, New York, New York, USA.
Charles BernickCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.
Robert C CantuBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Michael J ColemanPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Mass General Hospital, Boston, Massachusetts, USA.
David W DodickDepartment of Neurology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Elaine R PeskindVeterans Affairs Northwest Mental Illness Research, Education, and Clinical Center, Seattle, Washington, USA.
Christopher NowinskiBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Monica LyDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Caroline AltarasDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Steven LenioDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Gil D RabinoviciDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, California, USA.
Breton AskenDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA.
Howard RosenDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, California, USA.
Yann CobigoDepartment of Neurology, Alzheimer's Disease Research Center, Memory & Aging Center, University of California San Francisco, San Francisco, California, USA.
Jan Krzysztof BlusztajnDepartment of Pathology and Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Andrew E BudsonDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Katherine TurkBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Wei Qiao QiuBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Lee GoldsteinBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Brett MartinBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Joseph N PalmisanoBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Diane DixonBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Greta SchneiderBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Eric G SteinbergBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Yi SuBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
Hillary ProtasBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Mass General Hospital, Boston, Massachusetts, USA.
Inga KoertePsychiatry Neuroimaging Laboratory, Department of Psychiatry, Mass General Hospital, Boston, Massachusetts, USA.
Sylvain BouixDepartment of Software Engineering and Information Technology, École de technologie supérieure, Montreal, QC, Canada.
Jeffrey L CummingsChambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Eric M ReimanBanner Alzheimer's Institute and Arizona Alzheimer's Consortium, Phoenix, Arizona, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Mass General Hospital, Boston, Massachusetts, USA.
Robert A SternDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Ann C McKeeDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Thor D SteinBoston University Alzheimer's Disease Research Center and BU CTE Center, Boston, Massachusetts, USA.
Adam M BrickmanTaub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Jesse MezDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Michael L AloscoDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.

Funding

ADRC Consortium for Clarity in ADRD Research Through ImagingU01AG082350 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sarah Biber, BRADFORD C DICKERSON · 2023 to 2026
$90.0M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
RL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ann C. McKee · 2021 to 2026
$25.6M
Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Ranjan Duara, DAVID LOEWENSTEIN · 2020 to 2026
$25.6M
Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI JESSICA KIRKLAND CALDWELL · 2015 to 2026
$22.8M
Risk and Resilience, Clinical presentation, and Biomarker Profiles of Chronic Traumatic Encephalopathy and Related Dementias: The DIAGNOSE CTE Research Project IIR01NS139383 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Michael Alosco, Nicholas Ashton · 2024 to 2026
$9.3M
Early Onset Alzheimer's Disease ConsortiumR56AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2017 to 2017
$7.7M
Reimagining Precision Medicine Approaches to AD DiagnosisR35AG072362 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL, RABINOVICI, GIL DAN · 2021 to 2025
$4.8M
Age-Associated Lipidomic Changes in Alzheimer's DiseaseRF1AG057768 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BLUSZTAJN, JAN KRZYSZTOF, STEIN, THOR · 2019 to 2021
$4.5M
Alzheimer's Clinical Trial InnOvatioN (ACTION) InitiativeR35AG071476 · NIA · UNIVERSITY OF NEVADA LAS VEGAS · PI CUMMINGS, JEFFREY L. · 2021 to 2025
$2.9M
Digital Cognitive Assessment of Preclinical Alzheimer's Disease and Related DementiasR01AG083735 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Rhoda Au, Vijaya B. Kolachalama · 2024 to 2026
$2.4M
Department of Defense HT9425-24-1-1046NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG072978NIA NIH HHS P30AG072978NIA NIH HHS R01 AG083735NIA NIH HHS R01AG083735NIA NIH HHS R01 AG084624NIA NIH HHS R35 AG071476NIA NIH HHS R35 AG072362NIA NIH HHS R56 AG057195NIA NIH HHS RF1 AG057768NIA NIH HHS RF1 AG078299NIA NIH HHS U01 AG057195NIA NIH HHS U01 AG082350NIGMS NIH HHS P20 GM109025NINDS/NIA R01NS122854NINDS/NIA R01NS139383NINDS NIH HHS R01 NS122854NINDS NIH HHS R01 NS139383
6 · The paper itself

Abstract

introductionRepetitive head impacts (RHI) from contact sports may cause a unique pattern of white matter hyperintensities (WMH) on T2-weighted fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), termed RHI-associated WMH (RHI-WMH). These lesions are punctate, circular, and located at the gray-white matter boundary, an area vulnerable to trauma-related damage.

methodsWe investigated the association of RHI with these lesions in two aging cohorts: (1) former American football players versus asymptomatic unexposed men and (2) individuals with RHI from various contact sports versus non-RHI participants. RHI-WMH were assessed using visual ratings and a novel automated quantification pipeline.

resultsIndividuals with RHI had greater RHI-WMH by both detection methods in both cohorts. RHI-WMH were associated with plasma neurofilament light and p-tau231, and flortaucipir positron emission tomography (PET) uptake. DISCUSSION: RHI-WMH may represent a new supportive biomarker for the detection of RHI-related neuropathologies later in life.

Indexed as

Brain ConcussionMagnetic Resonance ImagingWhite MatterAgedBrainFootballHumansMaleMiddle AgedPositron-Emission TomographyCTEhead injuryrepetitive head impactssportswhite matter injury

Identifiers

PMID42002804
PMCPMC13092423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.