Evidence map›Paper›PMID 42002796›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Mixture of organic pollutants is associated with cognitive aging.

Vrinda Kalia, Katherine E Manz, Jaime Benavides, Suhang Song, Brandi L Vollmer, Beizhan Yan, Jeff Goldsmith, Kurt D Pennell, Yaakov Stern, Marianthi-Anna Kioumourtzoglou and 3 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Mixture of organic pollutants is associated with cognitive aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vrinda KaliaDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.ORCID 0000-0003-2244-6663
Katherine E ManzDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Jaime BenavidesDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Suhang SongDepartment of Health Policy and Management, College of Public Health, University of Georgia, Athens, Georgia, USA.
Brandi L VollmerDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Beizhan YanLamont-Doherty Earth Observatory, Columbia University, Palisades, New York, USA.
Jeff GoldsmithDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
Kurt D PennellSchool of Engineering, Brown University, Providence, Rhode Island, USA.
Yaakov SternDepartments of Neurology, Psychiatry, G.H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Marianthi-Anna KioumourtzoglouDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Gary W MillerDepartment of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.
Christian HabeckDepartment of Neurology and Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Yian GuDepartment of Neurology, G.H. Sergievsky Center and Taub Institute for Research on Alzheimer's Disease and The Aging Brain, Vagelos College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Vesicular Modulation of Dopamine Neuron ToxicityR01ES023839 · NIEHS · EMORY UNIVERSITY · PI MILLER, GARY W · 2015 to 2025
$5.0M
NEXUS: Network for Exposomics in the U.S.U24ES036819 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rima Habre, GARY W MILLER · 2024 to 2026
$4.6M
Diet and Cognition within a Reserve frameworkR01AG061008 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GU, YIAN · 2020 to 2024
$3.3M
Network biology-based markers of extreme weather-induced neurodegenerationP20AG093975 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2024 to 2025
$2.8M
Principal Component Pursuit to Assess Exposure to Environmental Mixtures in Epidemiologic StudiesR01ES028805 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2018 to 2021
$2.2M
NIA NIH HHS P20 AG093975NIA NIH HHS R01 AG061008NIEHS NIH HHS P30 ES009089NIEHS NIH HHS R01 ES023839NIEHS NIH HHS R01 ES028805NIEHS NIH HHS U24 ES036819
6 · The paper itself

Abstract

introductionEnvironmental organic pollutants impact brain function and cognitive aging, but the effect of real-world complex mixtures of these pollutants is unexplored.

methodsUsing data collected at two time points from 170 cognitively normal adults, we used hierarchical Bayesian kernel machine regression to examine the association between joint exposure to 49 organic pollutants and latent variables derived from neuropsychological tests that capture key aspects of cognitive aging.

resultsWe observed a non-linear, inverted U-shaped relationship between the pollutant mixture and the global cognitive score. Polychlorinated biphenyls (PCBs) were the most important pollutant group in the mixture followed by industrial-use pollutants. DISCUSSION: Exposure to a mixture of organic pollutants was associated with poor cognitive aging. Even though many of these pollutants, like PCBs, have been banned for decades, they persist in our environment. Strategies to reduce exposure to these organic pollutants are needed to minimize their impact on cognitive aging.

Indexed as

Cognitive AgingEnvironmental ExposurePersistent Organic PollutantsAdultAgedAged, 80 and overBayes TheoremFemaleHumansLatent Class AnalysisMaleMiddle AgedNeuropsychological TestsPolychlorinated BiphenylsRegression AnalysisYoung AdultPersistent Organic PollutantsPolychlorinated Biphenylscognitive agingexposomepolychlorinated biphenyls

Identifiers

PMID42002796
PMCPMC13092418

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.