ArticleAnnals of surgical oncology2026
The Prognostic Role of Postoperative Inflammation After Minimally Invasive Resection for Colorectal Cancer.
Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
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6 authors.
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Abstract
backgroundThe relationship between inflammation and tumorigenesis has been widely investigated, with tumor-promoting inflammation proposed as an "enabling characteristic." However, little is known about the prognostic value of surgery-related inflammation. This study evaluates whether postoperative inflammation affects prognosis in patients operated for colorectal cancer (CRC).
methodsConsecutive patients undergoing elective minimally invasive curative surgery for stage I-III CRC between 2014 and 2022 were included. Patients were divided into two groups based on the highest C-reactive protein (CRP) value measured within 30 days from surgery. Receiver operating characteristics curve analysis identified an optimal cutoff of 151.5 mg/L (area under the curve = 0.599), defining low-CRP (L-CRP) and high-CRP (H-CRP) groups. The primary endpoint was recurrence-free survival; secondary endpoints included overall survival (OS), cancer-specific survival (CSS), and recurrence pattern.
resultsA total of 436 patients were analysed. Recurrence-free survival (p = 0.005) was significantly worse in the H-CRP group, as were OS (p < 0.001) and CSS (p = 0.001). Subgroup analysis confirmed results only in stage III. Regarding pT, no differences were found in early pT patients, while significance was maintained for pT3 and pT4. The H-CRP group showed a higher proportion of locoregional and peritoneal metastases (p = 0.018). On multivariate analysis, H-CRP was an independent risk factor for recurrence (p = 0.02), alongside rectal location (p = 0.001), lymphovascular invasion (p = 0.014), and stage III (p = 0.001).
conclusionsThis study highlights the potential role of postoperative CRP as a negative prognostic factor for recurrence-free survival following curative resection for CRC.
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