Evidence map›Paper›PMID 42002687›Full record

ArticleNeurosurgical review2026

Impact of genetic profiles on periventricular anastomosis following bypass surgery in moyamoya disease.

Seiei Torazawa, Satoru Miyawaki, Hideaki Imai, Hiroki Hongo, Masahiro Shimizu, Hideaki Ono, Shotaro Ogawa, Yu Sakai, Satoshi Kiyofuji, Satoshi Koizumi and 4 more

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Article in Neurosurgical review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Seiei TorazawaDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Satoru MiyawakiDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan. smiya-nsu@m.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-6369-3391
Hideaki ImaiDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Hiroki HongoDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Masahiro ShimizuDepartment of Neurosurgery, Kanto Neurosurgical Hospital, Saitama, Japan.
Hideaki OnoDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Shotaro OgawaDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Yu SakaiDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Satoshi KiyofujiDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Satoshi KoizumiDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.
Daisuke KomuraDepartment of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Hiroto KatohDepartment of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Shumpei IshikawaDepartment of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Nobuhito SaitoDepartment of Neurosurgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative regression of periventricular anastomosis (PA) may have important implications for preventing hemorrhagic events in patients with moyamoya disease (MMD). We aimed to identify the genetic factors associated with postoperative PA regression. This retrospective cohort study enrolled 81 patients (102 hemispheres) who underwent combined revascularization surgery. PA types (lenticulostriate, choroidal, and thalamic) were scored from 0 to 2 preoperatively and postoperatively using magnetic resonance angiography, and postoperative regression was evaluated. We extracted all exonic variants in RNF213 and analyzed differences in their effects on PA regression between the p.Arg4810Lys variant and other RNF213 variants. Among the 81 participants, 51 (63.0%) carried p.Arg4810Lys (all heterozygotes: GA group), whereas 20 (24.5%) harbored other rare or damaging RNF213 variants (GG with other variants group). All types of PA regressed significantly in the GA group (P < 0.001 for all), whereas only choroidal PA showed significant regression in the GG with other variants group (P = 0.024). The postoperative decrease in choroidal PA score was greater in the GG with other variants group than in the GA group (P = 0.058). Multivariate analysis using linear mixed-effect models suggested a potential association between choroidal PA score reduction and two factors: the GG genotype with other variants and age < 16 years. Our findings indicate that harboring RNF213 variants other than p.Arg4810Lys may be associated with greater regression of choroidal PA compared with harboring p.Arg4810Lys in this exploratory cohort. Comprehensive genetic analysis of RNF213 may enable more accurate prediction of the surgical preventive effect on hemorrhagic events in MMD.

Indexed as

Adenosine TriphosphatasesCerebral RevascularizationMoyamoya DiseaseUbiquitin-Protein LigasesAdolescentAdultAnastomosis, SurgicalChildFemaleHumansMagnetic Resonance AngiographyMaleRetrospective StudiesYoung AdultAdenosine TriphosphatasesRNF213 protein, humanUbiquitin-Protein LigasesBypass surgeryChoroidal anastomosisMoyamoya diseasePeriventricular anastomosisRare VariantRNF213

Identifiers

PMID42002687
PMCPMC13092527

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.