Evidence map›Paper›PMID 42002676›Full record

ArticleDrug delivery and translational research2026

Rapid synthesis of redox-responsive trithiocyanuric acid-based nanocarriers: in vitro multidrug resistance reversal and in vivo safety assessment.

Elena Kopoleva, Sergey A Tsymbal, Oleg A Kuchur, Daria S Kulchanovskaya, Anna Yu Grishina, Alevtina A Pinova, Ilia V Doroshenko, Roman I Romanov, Albert R Muslimov, Alexander V Syuy and 7 more

Abstract read
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In one paragraph

Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Elena KopolevaBridge Center, Faculty of Physics, ITMO University, Lomonosova 9, Saint Petersburg, 191002, Russia.
Sergey A TsymbalLaboratory of Bio- and Cheminformatics, School of Computer Science, Physics and Technology, HSE University, 190121, Saint Petersburg, Russia.
Oleg A KuchurLaboratory of Bio- and Cheminformatics, School of Computer Science, Physics and Technology, HSE University, 190121, Saint Petersburg, Russia.
Daria S KulchanovskayaSaint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia.
Anna Yu GrishinaSaint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia.
Alevtina A PinovaLaboratory of Bio- and Cheminformatics, School of Computer Science, Physics and Technology, HSE University, 190121, Saint Petersburg, Russia.
Ilia V DoroshenkoEnergy Lab, ITMO University, Lomonosova 9, St. Petersburg, 191002, Russian Federation.
Roman I RomanovDepartment of SolidState Physics and Nanosystems, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 31 Kashirskoe Sh., Moscow, 115409, Russia.
Albert R MuslimovSaint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia.
Alexander V SyuyMoscow Center for Advanced Studies, Kulakova Str. 20, Moscow, Russian Federation.
Dmitry Yu IvkinSaint Petersburg State Chemical and Pharmaceutical University, Saint Petersburg, Russia.
Valeriy M KondratevMoscow Center for Advanced Studies, Kulakova Str. 20, Moscow, Russian Federation.
Svetlana RodimovaInstitute of Experimental Oncology and Biomedical Technologies, Minin and Pozharsky Sq, Privolzhsky Research Medical University, 10/1 , 603005, Nizhny Novgorod, Russia.
Kirill V LepikRM Gorbacheva Research Institute of Pediatric Oncology, Hematology and Transplantation, Pavlov University, 191144, St. Petersburg, Russian Federation.
Alexey D BolshakovMoscow Center for Advanced Studies, Kulakova Str. 20, Moscow, Russian Federation.
Oleksii O PeltekBridge Center, Faculty of Physics, ITMO University, Lomonosova 9, Saint Petersburg, 191002, Russia. aleksey.peltek@metalab.ifmo.ru.
Mikhail V ZyuzinBridge Center, Faculty of Physics, ITMO University, Lomonosova 9, Saint Petersburg, 191002, Russia. mikhail.zyuzin@metalab.ifmo.ru.ORCID http://orcid.org/0000-0002-5364-2635

Funding

Russian Science Foundation 24-75-10006Russian Science Foundation 25-73-10173
6 · The paper itself

Abstract

Multidrug resistance (MDR) remains one of the principal challenges in cancer chemotherapy, necessitating new strategies to restore drug efficacy. In this study we developed and characterize a redox-responsive nanoplatform based on trithiocyanuric acid and polyethylene glycol (TTCA-PEG NPs) as a potential tool to overcome MDR and provide a biocompatible delivery system for conventional antitumor drugs. The platform was evaluated using doxorubicin (DOX), bleomycin (Bleo), or cisplatin (Cis) each pre-loaded into TTCA-PEG NPs and tested across three pairs of drug-sensitive and resistant cancer cell lines. TTCA-PEG NPs reduced drug resistance from 2- to 5 fold compared with free drug, consistent with the recovery of intracellular drug accumulation and cytotoxic activity. The nanoplatform was synthesized through a one-step process completed within one hour, offering substantial simplification compared with conventional redox-responsive systems. Mechanistic studies revealed that treatment induced G

Indexed as

Cell deathCytotoxicityDrug resistanceRedoxresponsive nanoparticlesTrithiocyanuric acid

Identifiers

PMID42002676

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