Evidence map›Paper›PMID 42002637›Full record

ArticleActa diabetologica2026

Association between diabetes and tinnitus traits in the UK Biobank: a population-based cohort study.

Xiaoqin Ji, Ziyan Zhang, Xiuli Shao, Rong Yu, Deying Gu, Jianjun Ren, Huiling Zhao

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Article in Acta diabetologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Xiaoqin Ji *Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan Province, China.
Ziyan Zhang *Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan Province, China.
Xiuli ShaoDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan Province, China.
Rong YuDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan Province, China.
Deying GuDepartment of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan Province, China.
Jianjun Ren *Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan Province, China. Jianjun.Ren@scu.edu.cn.ORCID http://orcid.org/0000-0002-5938-688X
Huiling Zhao *Department of Otolaryngology-Head and Neck Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, No. 37 Guoxue Road, Chengdu, 610041, Sichuan Province, China. 15710087@163.com.

Funding

Chengdu Municipal Science and Technology Program 2022-YF05-01387-SNChengdu Municipal Science and Technology Program 2024-YF05-00908-SNHealth Department of Sichuan Province 21PJ021The Foundation of National Clinical Research Center for Geriatrics Z2023LC002The Science and Technology Department of Sichuan Province 2024NSFSC1510The Science and Technology Department of Sichuan Province 2024NSFSC1513The Science and Technology Department of Sichuan Province 2024YFHZ0076The Science and Technology Department of Sichuan Province 2024YFHZ0335West China Hospital, Sichuan University 2023HXBH119West China Hospital, Sichuan University 2023HXBH121West China Hospital, Sichuan University 2024HXBH111
6 · The paper itself

Abstract

objectivesTinnitus is common but challenging to treat. Investigating diabetes-related factors may inform prevention and targeted interventions. This study evaluated associations between diabetes-related factors and tinnitus traits.

methodsUsing UK Biobank data (n = 136,181), we performed cross-sectional logistic regression to evaluate links between diabetes status, HbA1c, medication use, and diabetes duration with tinnitus occurrence, frequency, and severity. Subgroup analyses assessed variations by sex and age.

resultsThis study systematically identified the associations between diabetes-related factors and the frequency and severity of tinnitus. Patients with type 2 diabetes had higher odds of experiencing current, constant, and upsetting tinnitus (OR: 2., 95% CI: 1.4-2.85, p = 0.001; OR: 2.49, 95% CI: 1.44-4.31, p = 0.0011; OR: 6.36, 95% CI: 2.3-17.54, p = 0.001, respectively). Insulin use was associated with lower odds of developing current, transient, and upsetting tinnitus compared to non-users of hypoglycemic drugs (OR: 0.61, 95% CI: 0.47-0.80; OR: 0.62, 95% CI: 0.43-0.9, p = 0.011; OR: 0.42, 95% CI: 0.25-0.69, p = 0.007, respectively). Subgroup analyses revealed stronger associations in younger females.

conclusionsType 2 diabetes increases tinnitus risk, whereas insulin use was associated with a lower prevalence of tinnitus. Notably, diabetes status and HbA1c were significantly associated with tinnitus, mainly in younger females.

Indexed as

Diabetes Mellitus, Type 2TinnitusAdultAgedBiological Specimen BanksCohort StudiesCross-Sectional StudiesFemaleGlycated HemoglobinHumansHypoglycemic AgentsInsulinMaleMiddle AgedUK BiobankUnited KingdomGlycated HemoglobinHypoglycemic AgentsInsulinDiabetes mellitusGlycated hemoglobinInsulinPreventionTinnitus

Identifiers

PMID42002637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.