Evidence map›Paper›PMID 42002588›Full record

ArticleScientific reports2026

Exosomal microRNA-4800-3p in portal vein blood promotes liver metastasis in pancreatic cancer by targeting PLAA.

Satoru Miyahara, Hidenori Takahashi, Yoshito Tomimaru, Shogo Kobayashi, Shinichiro Tahara, Kazuki Sasaki, Shinichiro Hasegawa, Yoshifumi Iwagami, Daisaku Yamada, Hirofumi Akita and 7 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Satoru MiyaharaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Hidenori TakahashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan. htakahashi8@gesurg.med.osaka-u.ac.jp.
Yoshito TomimaruDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Shogo KobayashiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Shinichiro TaharaDepartment of Pathology, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Kazuki SasakiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Shinichiro HasegawaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Yoshifumi IwagamiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Daisaku YamadaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Hirofumi AkitaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Tadafumi AsaokaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Takehiro NodaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Hiroshi WadaDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.
Junzo ShimizuDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Eiichi MoriiDepartment of Pathology, Graduate School of Medicine, The University of Osaka, 2-2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2 E2, Yamadaoka, Suita, 565-0871, Osaka, Japan.

Funding

JSPS KAKENHI 22K08823
6 · The paper itself

Abstract

This study aimed to identify exosomal microRNAs (exo-miRNAs) in portal vein blood (PVB) linked to liver metastasis in pancreatic cancer (PC) and elucidate the related molecular mechanisms. Exo-miRNAs were extracted from peripheral blood (PB) and PVB samples collected intraoperatively from patients with PC. Microarray analysis revealed that the exo-miRNA profiles associated with PC liver metastasis differed between PVB and PB. miR-4800-3p emerged as a potential exo-miRNA involved in liver metastasis and was highly expressed in PVB but not in PB. The overexpression (OE) of miR-4800-3p enhanced cell migration, invasion, and epithelial‒mesenchymal transition in vitro. mRNA sequencing revealed phospholipase A2 activating protein (PLAA) as a target mRNA regulated by miR-4800-3p. PLAA inhibits ubiquitination and prevents the degradation of methyltransferase like-3 protein, thereby enhancing the G protein-coupled receptor class C group 5 member A oncogene in vitro. In the in vivo PC liver metastasis model, the number of tumor nodules markedly increased in the miR-4800-3p OE group. Immunostaining of clinical samples revealed significantly lower PLAA expression in liver metastases than in lung metastases. These findings underscore the importance of PVB as a liquid sample for investigating liver metastasis-specific mechanisms that are undetectable using conventional PB analysis.

Indexed as

ExosomesLiver NeoplasmsMicroRNAsPancreatic NeoplasmsPortal VeinAnimalsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMiddle AgedMicroRNAsLiquid biopsyLiver metastasismiRNAPancreatic cancerPortal vein blood

Identifiers

PMID42002588
PMCPMC13254358

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.