Evidence map›Paper›PMID 42002542›Full record

ArticleNMR in biomedicine2026

Unique Peritumoral Patterns Unveiled by Quantitative Multiparametric MRI and Their Diagnostic and Prognostic Value in Treated Malignant Gliomas.

Keyi Chai, Puyang Wang, Austin Carmichael, Jingpu Wu, Zongpai Zhang, Qianqi Huang, Karisa C Schreck, Jordina Rincon-Torroella, Matthias Holdhoff, David O Kamson and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Keyi ChaiDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Puyang WangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Austin CarmichaelDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0009-0000-9362-1022
Jingpu WuDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Zongpai ZhangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Qianqi HuangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Karisa C SchreckDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jordina Rincon-TorroellaDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Matthias HoldhoffDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
David O KamsonDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Lindsay BlairDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Haris I SairDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Solmaz SahebjamDepartment of Oncology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jaishri O BlakeleyDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
John LaterraDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Chetan BettegowdaDepartment of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Jinyuan ZhouDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-6684-7920
Shanshan JiangDepartment of Radiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

Integrating circulating tumor DNA assay and protein-based MRI to accurately monitor glioma therapyR01CA276221 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHETAN BETTEGOWDA, Shanshan Jiang · 2023 to 2026
$2.7M
Quantitative CEST MRI for GBM Early Response Prediction and Biopsy GuidanceR37CA248077 · NCI · JOHNS HOPKINS UNIVERSITY · PI Shanshan Jiang · 2021 to 2026
$2.2M
Amide Proton Transfer (APT) MRI of Brain Tumors at 3TR01CA228188 · NCI · JOHNS HOPKINS UNIVERSITY · PI ZHOU, JINYUAN · 2019 to 2022
$1.6M
NCI NIH HHS R01 CA228188NCI NIH HHS R01 CA276221NCI NIH HHS R37 CA248077NIH HHS R01CA228188NIH HHS R01CA276221NIH HHS R37CA248077
6 · The paper itself

Abstract

Malignant gliomas remain among the most challenging brain tumors to manage, with high recurrence rates and difficulty in distinguishing progression from treatment-related changes. While the peritumoral region offers valuable insights into tumor behavior, its quantitative MRI characteristics remain largely underexplored. This study investigated the diagnostic and prognostic value of multiparametric MRI biomarkers from noncontrast-enhancing peritumoral regions, particularly the surrounding nonenhancing FLAIR hyperintensity (SNFH). Thirty-eight patients with treated malignant gliomas underwent amide proton transfer-weighted (APTw) imaging, T

Indexed as

Brain NeoplasmsGliomaMultiparametric Magnetic Resonance ImagingAdultAgedFemaleHumansMaleMiddle AgedPrognosisRadiomicsTreatment Outcomeamide proton transfer imagingglioblastomamagnetic resonance imagingperitumoral edematreatment effect

Identifiers

PMID42002542
PMCPMC13191571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.