Evidence map›Paper›PMID 42002534›Full record

ArticleNMR in biomedicine2026

Neurometabolic Stability and Heritability in the Adolescent Brain: A Preliminary Longitudinal Twin MRS Study.

Christoph Hamann, Andjela Markovic, Julien Caccia, Andrzej Badek, Salome Wild, Kristina Adorjan, Michael Kaess, Ruth Tuura, Leila Tarokh

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christoph HamannDivision of Child and Adolescent Psychiatry and Psychosomatic Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andjela MarkovicTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Julien CacciaDivision of Child and Adolescent Psychiatry and Psychosomatic Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Andrzej BadekDivision of Child and Adolescent Psychiatry and Psychosomatic Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Salome WildTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Kristina AdorjanTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Michael KaessUniversity Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
Ruth TuuraMR-Research Centre, University Children's Hospital Zurich, Zurich, Switzerland.
Leila TarokhTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-4014-428X

Funding

GE HealthcareJacobs FoundationSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 2003B_184943Swiss National Science FoundationUniversity of Bern
6 · The paper itself

Abstract

Early adolescence is a critical period of brain development. This study examined regional neurometabolite ratios, their longitudinal stability, and their heritability during early adolescence. Forty-four adolescent twins (mean age: 13.25 years; SD = 1.01 years; 18 females; 25 monozygotic twins) underwent magnetic resonance spectroscopy (MRS) of the prefrontal cortex (GABA-edited MEGA-PRESS) and thalamus (short-echo-time PRESS) at baseline and 6 months later (n = 32; mean age: 13.72 years; SD = 0.97; 14 females; 19 monozygotic twins). We observed stable neurometabolite ratios in both regions across time. Moderate genetic contributions were estimated for Glx (glutamate and glutamine)/(Cr + PCr) in the prefrontal cortex as well as for glutamate/(Cr + PCr) and total choline-containing compounds (PCho + GPC)/(Cr + PCr) in the thalamus. These preliminary findings highlight region-specific and genetically influenced neurometabolic markers in early adolescence.

Indexed as

BrainInheritance PatternsAdolescentChildCholineFemaleHumansLongitudinal StudiesMagnetic Resonance SpectroscopyMaleThalamusCholinedevelopmentearly adolescenceheritabilityMRSneurometabolites

Identifiers

PMID42002534
PMCPMC13092461

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.